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Comment
. 2021 Mar 8;22(1):255.
doi: 10.1186/s12891-021-04117-8.

The importance of appropriate diagnostics in prosthetic joint infection: letter to the editor of BMC musculoskeletal disorders

Martin McNally  1 , Marjan Wouthuyzen-Bakker  2 , Ricardo Sousa  3 , Bridget Atkins  4 , Alex Soriano  5
Affiliations
Comment

The importance of appropriate diagnostics in prosthetic joint infection: letter to the editor of BMC musculoskeletal disorders

Martin McNally et al. BMC Musculoskelet Disord. .

Abstract

Assessment of a new diagnostic test must be performed against an acceptable and validated standard to allow comparison with other studies. We are concerned that the adoption of lower diagnostic criteria in this paper has contributed to an over-diagnosis of prosthetic joint infection and makes interpretation of the results difficult.

Keywords: Diagnosis; Histology; Prosthetic joint infection; Synovial fluid culture.

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Conflict of interest statement

The authors declare no competing interests in this submission. We have received no funding, directly or indirectly related to the content of this letter. All authors are members of the European Bone & Joint Infection Society (EBJIS).

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References

    1. Morgenstern C, Renz N, Cabric S, Maiolo E, Perka C, Trampuz A. Thermogenic diagnosis of periprosthetic joint infection by microcalorimetry of synovial fluid. BMC Musculoskeletal Dis. 2020;21:345. doi: 10.1186/s12891-020-03366-3. - DOI - PMC - PubMed
    1. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008;90:1869–1875. doi: 10.2106/JBJS.G.01255. - DOI - PubMed
    1. Krenn V, Morawietz L, Perino G, Kienapfel H, Ascherl R, Hassenpflug GJ, Thomsen M, Thomas P, Huber M, Kendoff D, et al. Revised histopathological consensus classification of joint implant related pathology. Pathol Res Pract. 2014;210:779–786. doi: 10.1016/j.prp.2014.09.017. - DOI - PubMed
    1. Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R. Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med. 2004;117:556–562. doi: 10.1016/j.amjmed.2004.06.022. - DOI - PubMed
    1. Sousa R, Serrano P, Gomes Dias J, Oliveira JC, Oliveira A. Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers: C-reactive protein and adenosine deaminase. Bone Joint J. 2017;99-B(3):351–357. doi: 10.1302/0301-620X.99B3.BJJ-2016-0684.R1. - DOI - PubMed