Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 8;19(1):14.
doi: 10.1186/s12959-021-00268-9.

Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore

Chuen Wen Tan #  1 , Bingwen Eugene Fan #  2   3 , Winnie Z Y Teo  4   5 , Moon Ley Tung  4 , Humaira Shafi  6 , Dheepa Christopher  2   3 , Shuwei Zheng  7 , Wee Ming Peh  7   8 , Stephrene Seok Wei Chan  2 , Vanessa Cui Lian Chong  2 , Christian Aledia Gallardo  2 , Cheng Chieh Ray Chang  2 , Li Min Ling  9 , Jing Yuan Tan  10 , Ken Cheah Hooi Lee  10 , Ghee Chee Phua  10 , Benjamin Pei Zhi Cherng  11 , Jenny Guek Hong Low  11   12 , Vui Kian Ho  8 , Vishnu Prasad  3 , Lester Jung Long Wong  13 , Cheryl Xiu Qi Lim  4 , Yen Lin Chee  4 , Kiat Hoe Ong  2 , Lai Heng Lee  1 , Heng Joo Ng  14 , Eng Soo Yap  15   16   17 ; Thrombosis Haemostasis Workgroup of Singapore Society of Haematology
Affiliations

Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore

Chuen Wen Tan et al. Thromb J. .

Abstract

Background: Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients.

Method and results: This is a national multicenter retrospective observational study involving all consecutive adult COVID-19 patients who required intensive care units (ICU) admission between 23 January 2020 and 30 April 2020 in Singapore. One hundred eleven patients were included and the venous and arterial thrombotic rates in ICU were 1.8% (n = 2) and 9.9% (n = 11), respectively. Major bleeding rate was 14.8% (n = 16).

Conclusions: Critically ill COVID-19 patients in Singapore have lower venous thromboembolism but higher arterial thrombosis rates and bleeding manifestations than other reported cohorts.

Keywords: COVID-19; Critical care; Thrombosis.

PubMed Disclaimer

Conflict of interest statement

The authors do not declare any competing interests.

References

    1. Iba T, Levy JH, Levi M, Connors JM, Thachil J. Coagulopathy of coronavirus disease 2019. Crit Care Med. 2020;48(9):1358–64. - PMC - PubMed
    1. Al-Ani F, Chehade S, Lazo-Langner A. Thrombosis risk associated with COVID-19 infection. A scoping review. Thromb Res. 2020;192:152–160. doi: 10.1016/j.thromres.2020.05.039. - DOI - PMC - PubMed
    1. Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, Kaptein FHJ, van Paassen J, Stals MAM, Huisman MV, Endeman H. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis. Thromb Res. 2020;191:148–150. doi: 10.1016/j.thromres.2020.04.041. - DOI - PMC - PubMed
    1. Zhang L, Feng X, Zhang D, Jiang C, Mei H, Wang J, Zhang C, Li H, Xia X, Kong S, et al. Deep vein thrombosis in hospitalized patients with coronavirus disease 2019 (COVID-19) in Wuhan, China: prevalence, risk factors and outcome. Circulation. 2020;142:114–128. doi: 10.1161/CIRCULATIONAHA.120.046702. - DOI - PubMed
    1. Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, Holley AB, Jimenez D, LeGal G, Rali P, Wells P. Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST guideline and expert panel report. Chest. 2020;158(3):1143–63. - PMC - PubMed

LinkOut - more resources