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. 2023 May 1;65(5):e02634-20.
doi: 10.1128/AAC.02634-20. Epub 2021 Mar 8.

Integrative and Conjugative Element-Mediated Azithromycin Resistance in Multidrug-Resistant Salmonella enterica serovar Albany

Yu-Ping Hong  1   2 , Ying-Tsong Chen  2 , You-Wun Wang  1 , Bo-Han Chen  1 , Ru-Hsiou Teng  1 , Yi-Syong Chen  1 , Chien-Shun Chiou  3
Affiliations

Integrative and Conjugative Element-Mediated Azithromycin Resistance in Multidrug-Resistant Salmonella enterica serovar Albany

Yu-Ping Hong et al. Antimicrob Agents Chemother. .

Abstract

We identified an erm42-carrying integrative and conjugative element, ICE_erm42, in 26.4% of multidrug-resistant Salmonella enterica serovar Albany isolates recovered from human salmonellosis between 2014 and 2019 in Taiwan. ICE_erm42-carrying strains displayed high-level resistance to azithromycin and the element could move into the phylogenetically distant Vibrio cholerae via conjugation.

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Figures

FIG 1
FIG 1
Genetic maps for ICE_erm42 from Salmonella Albany strain R17.5974 (GenBank accession number CP060730.1) and ICEValA056-1 from Vibrio alginolyticus strain A056 (accession number KR231688.1), drawn using Easyfig software (https://mjsull.github.io/Easyfig/). ORF, open reading frame.
FIG 2
FIG 2
cgMLST tree showing the genetic relatedness among the 66 most closely related isolates from Taiwan and 5 other countries, accompanied by the relevant genetic traits for the isolates. The tree was constructed using the unweighted pair group method with arithmetic mean algorithm and the tool provided in BioNumerics software version 7.6 (Applied Maths, Belgium). The isolates that originated from Taiwan but were recovered in other countries are marked with asterisks. Isolates harboring 4 MGEs (SGI1-F, prophage TW2, ICE_shufflon, and ICE_erm42) are marked with red squares, those harboring 3 MGEs (SGI1-F, prophage TW2, and ICE_shufflon) are marked with orange squares, those harboring 2 MGEs (SGI1-F and prophage TW2) are marked with green squares, and those harboring SGI1-F and prophage TW2 variants are marked with blue squares. 1, <1, and 0 represent, respectively, a complete copy, a partial copy, and zero copies of SGI1-F, prophage TW2, ICE_shufflon, and ICE_erm42.
FIG 3
FIG 3
cgMLST tree showing the phylogenetic relationships among the 66 most closely related isolates from Taiwan and the other 5 countries (China, Singapore, the United Kingdom, the United States, and Vietnam). The tree was constructed with cgMLST profiles using the neighbor-joining algorithm and the tool provided in BioNumerics software version 7.6 (Applied Maths, Belgium).
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