Deciphering cis-regulatory grammar with deep learning

Emily R Miraldi^{1

2

3}, Xiaoting Chen⁴, Matthew T Weirauch^{5

6

7

8}

Affiliations

¹ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
² Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
³ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁴ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁵ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁶ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁷ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁸ Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.

Comment

Emily R Miraldi et al. Nat Genet. 2021 Mar.

. 2021 Mar;53(3):266-268.

doi: 10.1038/s41588-021-00814-1.

Emily R Miraldi^{1

2

3}, Xiaoting Chen⁴, Matthew T Weirauch^{5

6

7

8}

¹ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
² Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
³ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁴ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁵ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁶ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁷ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.
⁸ Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Matthew.Weirauch@cchmc.org.

No abstract available

Comment on

Base-resolution models of transcription-factor binding reveal soft motif syntax.
Avsec Ž, Weilert M, Shrikumar A, Krueger S, Alexandari A, Dalal K, Fropf R, McAnany C, Gagneur J, Kundaje A, Zeitlinger J. Avsec Ž, et al. Nat Genet. 2021 Mar;53(3):354-366. doi: 10.1038/s41588-021-00782-6. Epub 2021 Feb 18. Nat Genet. 2021. PMID: 33603233 Free PMC article.

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