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Case Reports
. 2023 Oct;37(5):1354-1357.
doi: 10.1080/02688697.2021.1884650. Epub 2021 Mar 9.

Malignant vestibular schwannoma with intracerebral metastasis

Affiliations
Case Reports

Malignant vestibular schwannoma with intracerebral metastasis

Sayedeh Ameneh Salehi-Reyhani et al. Br J Neurosurg. 2023 Oct.

Abstract

Background: Malignant change in vestibular schwannoma is rare and intracranial metastatic deposits have not been reported.

Clinical presentation: We report the case of a 64 year old woman with a benign vestibular schwannoma who underwent translabyrinthine excision in 1996 and Gamma Knife® radiosurgery (Elekta AB, Stockholm, Sweden) (GKRS) in 2006. She presents 10 years after GKRS with progressive neurological deterioration. Histopathologic analysis confirms a malignant peripheral nerve sheath tumour, WHO grade IV with subsequent metastatic spread to the left thalamus confirmed on biopsy.

Conclusion: We report a rare case of a vestibular schwannoma metastasizing with histological confirmation. It also reminds us of malignant conversion of a benign vestibular schwannoma following GKRS and subsequent aggressive behaviour, with poor prognosis.

Keywords: Acoustic neuroma; gamma knife radiosurgery; malignant peripheral nerve sheath tumour (MPNST); neoplasm metastasis; oncology; vestibular schwannoma.

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