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. 2021 Mar 3;13(6):8290-8305.
doi: 10.18632/aging.202637. Epub 2021 Mar 3.

Clinical features and prognostic factors of patients with metastatic renal cell carcinoma stratified by age

Gu Yue  1 , Li Deyu  2 , Tao Lianyuan  2 , Shao Fengmin  1 , Gao Mei  1 , Huang Yajun  1 , Zhang Wenwen  1 , Yan Lei  1
Affiliations

Clinical features and prognostic factors of patients with metastatic renal cell carcinoma stratified by age

Gu Yue et al. Aging (Albany NY). .

Abstract

This study compared the clinicopathological characteristics and survival of patients with metastatic renal cell carcinoma (mRCC) stratified by age to identify clinical features and prognostic factors. Patients with renal cell carcinoma (RCC) between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database. Age was an independent prognostic factor for patients with RCC, mRCC, mRCC of clear cell renal cell carcinoma and lung-related metastases. There were many significant differences between the younger and older groups, including differences in marital status, race, sex, year of diagnosis, histology grade, laterality, T stage, N stage, tumor size, type of treatment, including surgery, radiation or chemotherapy, and pattern of organic metastasis to the liver, lung, or brain (P<0.05). Moreover, different natural metastasis patterns and poorer overall survival were observed in the older group compared with the younger group (P<0.05). Parameters, including marital status, sex, year of diagnosis, histological grade, N stage, surgery, chemotherapy, lung metastasis and liver metastasis, were independent prognostic factors for elderly patients (P<0.05). Age plays a significant role in mRCC, and elderly patients with mRCC are a special group of individuals whose clinical characteristics and prognostic factors are different from those of younger patients; therefore, these patients require special attention.

Keywords: elderly patients; metastasis; prognostic factors; renal cell carcinoma; survival.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Estimation of the cutoff values for age stratification, as determined by X-tile software.
Figure 2
Figure 2
Comparison of overall survival rates among patients with renal cell carcinoma and a single metastatic site in different age groups.
Figure 3
Figure 3
Comparison of overall survival rates among patients with renal cell carcinoma and two metastatic sites in different age groups.
See this image and copyright information in PMC

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