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Review
. 2021 Nov;83(11):e23250.
doi: 10.1002/ajp.23250. Epub 2021 Mar 9.

Prefrontal cortex and cognitive aging in macaque monkeys

Nicholas A Upright  1 , Mark G Baxter  1
Affiliations
Review

Prefrontal cortex and cognitive aging in macaque monkeys

Nicholas A Upright et al. Am J Primatol. 2021 Nov.

Abstract

Cognitive impairments that accompany aging, even in the absence of neurodegenerative diseases, include deficits in executive function and memory mediated by the prefrontal cortex. Because of the unique differentiation and expansion of the prefrontal cortex in primates, investigations of the neurobiological basis of cognitive aging in nonhuman primates have been particularly informative about the potential basis for age-related cognitive decline in humans. We review the cognitive functions mediated by specific subregions of prefrontal cortex, and their corresponding connections, as well as the evidence for age-related alterations in specific regions of prefrontal cortex. We also discuss evidence for similarities and differences in the effects of aging on prefrontal cortex across species.

Keywords: aging; executive function; prefrontal; rhesus; spatial memory.

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References

REFERENCES

    1. Alexander, G. E., Chen, K., Aschenbrenner, M., Merkley, T. L., Santerre-Lemmon, L. E., Shamy, J. L., Skaggs, W. E., Buonocore, M. H., Rapp, P. R., & Barnes, C. A. (2008). Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. Journal of Neuroscience, 28(11), 2710-2718. https://doi.org/10.1523/JNEUROSCI.1852-07.2008
    1. Alzheimer's Association. (2020). 2020 Alzheimer's disease facts and figures. https://www.alz.org/media/Documents/alzheimers-facts-and-figures.pdf
    1. Arnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019). Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America, 116(52), 26230-26238. https://doi.org/10.1073/pnas.1903671116
    1. Bachevalier, J., Landis, L. S., Walker, L. C., Brickson, M., Mishkin, M., Price, D. L., & Cork, L. C. (1991). Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiology of Aging, 12, 99-111. https://doi.org/10.1016/0197-4580(91)90048-o
    1. Bachevalier, J., & Mishkin, M. (1986). Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys. Behavioural Brain Research, 20(3), 249-261. https://doi.org/10.1016/0166-4328(86)90225-1

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