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Clinical Trial
. 2021 Apr;199(2):195-198.
doi: 10.1007/s00408-021-00430-0. Epub 2021 Mar 9.

Comparison of Multiple Diagnostic Tests to Measure Dynamic Hyperinflation in Patients with Severe Emphysema Treated with Endobronchial Coils

Marlies van Dijk  1 , Jorine E Hartman  2 , Sonja W S Augustijn  2 , Nick H T Ten Hacken  2 , Karin Klooster  2 , Dirk-Jan Slebos  2
Affiliations
Clinical Trial

Comparison of Multiple Diagnostic Tests to Measure Dynamic Hyperinflation in Patients with Severe Emphysema Treated with Endobronchial Coils

Marlies van Dijk et al. Lung. 2021 Apr.

Abstract

Purpose: For this study, we aimed to compare dynamic hyperinflation measured by cardiopulmonary exercise testing (CPET), a six-minute walking test (6-MWT), and a manually paced tachypnea test (MPT) in patients with severe emphysema who were treated with endobronchial coils. Additionally, we investigated whether dynamic hyperinflation changed after treatment with endobronchial coils.

Methods: Dynamic hyperinflation was measured with CPET, 6-MWT, and an MPT in 29 patients before and after coil treatment.

Results: There was no significant change in dynamic hyperinflation after treatment with coils. Comparison of CPET and MPT showed a strong association (rho 0.660, p < 0.001) and a moderate agreement (BA-plot, 202 ml difference in favor of MPT). There was only a moderate association of the 6-MWT with CPET (rho 0.361, p 0.024).

Conclusion: MPT can be a suitable alternative to CPET to measure dynamic hyperinflation in severe emphysema but may overestimate dynamic hyperinflation possibly due to a higher breathing frequency.

Keywords: COPD; Dynamic hyperinflation; Emphysema; Endobronchial coils.

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Conflict of interest statement

MD, JH, SA, NH, and KK have no real or perceived competing interests. DS reports grants and non-financial support from PneumRx/BTG, outside the submitted work.

Figures

Fig. 1
Fig. 1
A Bland–Altman plot of dynamic hyperinflation measured by cardiopulmonary exercise testing (CPET) and a manually paced tachypnea test (MPT)
See this image and copyright information in PMC

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