Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;87(5):717-719.
doi: 10.1007/s00280-021-04241-1. Epub 2021 Mar 9.

Detecting DPD deficiency: when perfect is the enemy of good

Joseph Ciccolini  1 , Gérard Milano  2 , Henk-Jan Guchelaar  3
Affiliations

Detecting DPD deficiency: when perfect is the enemy of good

Joseph Ciccolini et al. Cancer Chemother Pharmacol. 2021 May.
No abstract available

PubMed Disclaimer

References

    1. Burns KE, Chavani O, Jeong SH et al (2020) Comparison of a thymine challenge test and endogenous uracil–dihydrouracil levels for assessment of fluoropyrimidine toxicity risk. Cancer Chemother Pharmacol (EPub Ahead of Print)
    1. Ciccolini J, Mercier C, Dahan L et al (2006) Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency. Cancer Chemother Pharmacol 58:272–275 - DOI
    1. Gamelin E, Boisdron-Celle M, Guérin-Meyer V et al (1999) Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: a potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage. J Clin Oncol 17:1105 - DOI
    1. Ciccolini J, Gross E, Dahan L, Lacarelle B, Mercier C (2010) Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope? Clin Colorectal Cancer 9:224–228 - DOI
    1. Meulendijks D, Henricks LM, Sonke GS et al (2015) Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data. Lancet Oncol 16:1639–1650 - DOI

MeSH terms

Substances

LinkOut - more resources