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Review
. 2021 Jul;476(7):2739-2752.
doi: 10.1007/s11010-021-04120-6. Epub 2021 Mar 9.

Mechanistic insights into the pathogenesis of neurodegenerative diseases: towards the development of effective therapy

Fauzia Nazam #  1 , Sibhghatulla Shaikh #  2 , Nazia Nazam  3 , Abdulaziz Saad Alshahrani  4 , Gulam Mustafa Hasan  5 , Md Imtaiyaz Hassan  6
Affiliations
Review

Mechanistic insights into the pathogenesis of neurodegenerative diseases: towards the development of effective therapy

Fauzia Nazam et al. Mol Cell Biochem. 2021 Jul.

Abstract

Neurodegeneration is a prevalent and one of the emerging reasons for morbidity, mortality, and cognitive impairment in aging. Dementia is one of such conditions of neurodegeneration, partially manageable, irreversible, and worsens over time. This review is focused on biological and psychosocial risk factors associated with Alzheimer's and Parkinson's diseases, highlighting the value of cognitive decline. We further emphasized on current therapeutic strategies from pharmacological and non-pharmacological perspectives focusing on their effects on cognitive impairment, protein aggregation, tau pathology, and improving the quality of life. Deeper mechanistic insights into the multifactorial neurodegeneration could offer the design and development of promising diagnostic and therapeutic strategies.

Keywords: Alzheimer’s disease; Parkinson’s disease; Neurodegeneration; Neurodegenerative diseases; Therapeutic management.

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References

    1. Enache D, Winblad B, Aarsland D (2011) Depression in dementia: epidemiology, mechanisms, and treatment. Curr Opin Psychiatry 24:461–472 - PubMed
    1. Kasl-Godley J, Gatz M (2000) Psychosocial interventions for individuals with dementia: an integration of theory, therapy, and a clinical understanding of dementia. Clin Psychol Rev 20:755–782 - PubMed
    1. Kumar V, Sami N, Kashav T, Islam A, Ahmad F, Hassan MI (2016) Protein aggregation and neurodegenerative diseases: from theory to therapy. Eur J Med Chem 124:1105–1120 - PubMed
    1. Voet S, Srinivasan S, Lamkanfi M, van Loo G (2019) Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO Mol Med 11:e10248 - PubMed - PMC
    1. Rocca WA (2018) The burden of Parkinson’s disease: a worldwide perspective. Lancet Neurol 17:928–929 - PubMed

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