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. 2021 Feb 20:2021:5590110.
doi: 10.1155/2021/5590110. eCollection 2021.

Oral Microbial Diversity Formed and Maintained through Decomposition Product Feedback Regulation and Delayed Responses

Chen Dong  1 , Dandan Li  1 , Zengfeng Wang  2 , Zhengde Bao  3
Affiliations

Oral Microbial Diversity Formed and Maintained through Decomposition Product Feedback Regulation and Delayed Responses

Chen Dong et al. Evid Based Complement Alternat Med. .

Abstract

Oral microbial diversity plays an important role on oral health maintenance. However, there are only few kinds of substrates available for the microbial flora in oral cavity, and it still remains unclear why oral microbial diversity can be formed and sustained without obvious competitive exclusion. Based on experimental phenomena and data, a new hypothesis was proposed, namely, the decomposition product negative feedback regulation on microbial population size and microbial delay responses including reproductive, reaction, interspecific competition, and substrate decomposition delay responses induced by oral immunity. According to hypothesis and its cellular automata (CA) model, the CA simulation results sufficiently proved that the decomposition product negative feedback regulation and four microbial delay responses could significantly alleviate the interspecific competitions and inhibit the emergence of dominant species, causing the formation and sustenance of oral microbial diversity. This study could also offer effective guidance of prevention and treatment of oral cavity diseases.

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Conflict of interest statement

The authors declare no conflicts of interest in this article.

Figures

Figure 1
Figure 1
Dynamic characteristics of microbial populations and Simpson α diversity in oral cavity.
Figure 2
Figure 2
Variation of intracellular triglyceride content and specific growth rate of microbial populations in natural environment and oral cavity.
Figure 3
Figure 3
Microbial population dynamic response characteristics without and with delay effects.
Figure 4
Figure 4
CA neighbor type.
Figure 5
Figure 5
Pattern of microbial community spatiotemporal succession process in oral cavity.
Figure 6
Figure 6
Cluster analysis of climax microbial community resulting from CA simulation in oral cavity.
Figure 7
Figure 7
Dynamic response characteristics of oral microbial populations without (top) and with (bottom) delay effect community spatiotemporal succession process in oral cavity.
Figure 8
Figure 8
Simpson α index dynamics of oral microbial community without and with delay effects.
See this image and copyright information in PMC

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