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Comment
. 2021 Mar 8;56(5):571-572.
doi: 10.1016/j.devcel.2021.02.014.

Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production

Jenna M Frame  1 , Trista E North  2
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Comment

Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production

Jenna M Frame et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Weinreb et al. reveal that loss of the DEAD-box helicase Ddx41 unexpectedly triggers an R-loop-mediated sterile inflammatory cascade which drives HSPC production during embryonic development. Human studies suggest mechanistic conservation for inflammation in DDX41-associated hematologic disease, uncovering a potential route for future therapeutic intervention.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

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