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. 2022 Sep;28(6):1715-1722.
doi: 10.1111/odi.13842. Epub 2021 Mar 21.

Periodontitis in Italian patients with established rheumatoid arthritis: A cross-sectional study

Dimitra Karapetsa  1 , Arianna Consensi  2 , Giulia Castagnoli  3 , Morena Petrini  3   4 , Matteo Tonelli  1 , Stefano Gennai  1 , Laura Bazzichi  2 , Filippo Graziani  1
Affiliations

Periodontitis in Italian patients with established rheumatoid arthritis: A cross-sectional study

Dimitra Karapetsa et al. Oral Dis. 2022 Sep.

Abstract

Objective: To assess the prevalence and severity of periodontitis (P) among Italian patients affected by rheumatoid arthritis (RA).

Materials and methods: A full-mouth periodontal examination and a rheumatologic examination were performed. RA disease activity was scored using the DAS28. Serum analyses investigated levels of rheumatoid factor, anti-citrullinated protein antibodies (ACPAs), C-reactive protein, erythrocyte sedimentation rate and fibrinogen. Information concerning smoking, body mass index and RA medical therapy was collected. Data were analysed by Student's t test, chi-square test, binary logistic regression and Spearman's rank.

Results: This cross-sectional study included 120 subjects, 77 had both diseases while 43 only had RA. The number of teeth present was statistically lower in the RA-P compared to the RA group (p < .05). There were statistically more subjects seropositive for ACPAs in the RA-P group (62.3% vs. 32.6%, p < .05). RA-P patients had an adjusted OR = 2.9 of presenting a moderate-severe DAS28 score (DAS28 ≥ 3.2).

Conclusions: Higher prevalence of severe P was noted among RA subjects. The clinical severity of RA was strongly correlated with the clinical periodontal parameters, and RA subjects also affected by P had an OR of 2.9 for presenting with a moderate-severe RA (DAS28 score ≥ 3.2).

Keywords: Italian; disease activity; periodontitis; prevalence; rheumatoid arthritis.

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References

REFERENCES

    1. Ainamo, J., & Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25, 229-235.
    1. Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., Combe, B., Costenbader, K. H., Dougados, M., Emery, P., Ferraccioli, G., Hazes, J. M. W., Hobbs, K., Huizinga, T. W. J., Kavanaugh, A., … Hawker, G. (2010). 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis and Rheumatism, 62(9), 2569-2581. https://doi.org/10.1002/art.27584
    1. Araujo, V. M., Melo, I. M., & Lima, V. (2015). Relationship between periodontitis and rheumatoid arthritis: Review of the liter- ature. Mediators of Inflammation, 259074. https://doi.org/10.1155/2015/259074
    1. Baka, Z., Buzas, E., & Nagy, G. (2009). Rheumatoid arthritis and smoking: Putting the pieces together. Arthritis Research and Therapy, 11(4), 238. https://doi.org/10.1186/ar2751
    1. Bonfil, J., Dillier, F., Mercier, P., Reviron, D., Foti, B., Sambuc, R., Brodeur, J., & Sedarat, C. (1999). A “case control” study on the rôle of HLA DR4 in severe periodontitis and rapidly progressive periodontitis Identification of types and subtypes using molecular biology (PCR.SSO). Journal of Clinical Periodontology, 26(2), 77-84. https://doi.org/10.1034/j.1600-051X.1999.260203.x

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