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Comment
. 2021 Apr 7;29(4):1363-1365.
doi: 10.1016/j.ymthe.2021.03.001. Epub 2021 Mar 10.

Doxorubicin-induced cardiomyopathy: TERT gets to the heart of the matter

Bart De Geest  1 , Mudit Mishra  2
Affiliations
Comment

Doxorubicin-induced cardiomyopathy: TERT gets to the heart of the matter

Bart De Geest et al. Mol Ther. .
No abstract available

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Figures

Figure 1
Figure 1
Redox cycling of doxorubicin in the mitochondria Doxorubicin is bioactivated by complex I of the mitochondrial respiratory chain at the expense of NADH. This is followed by the rapid re-oxidation of the semiquinone radical in the presence of molecular oxygen to generate superoxide anion-free radicals. Subsequently, further primary reactive oxygen species and secondary reactive oxygen species are produced, leading to oxidative stress.
See this image and copyright information in PMC

Comment on

  • Telomerase therapy attenuates cardiotoxic effects of doxorubicin.
    Chatterjee S, Hofer T, Costa A, Lu D, Batkai S, Gupta SK, Bolesani E, Zweigerdt R, Megias D, Streckfuss-Bömeke K, Brandenberger C, Thum T, Bär C. Chatterjee S, et al. Mol Ther. 2021 Apr 7;29(4):1395-1410. doi: 10.1016/j.ymthe.2020.12.035. Epub 2021 Jan 1. Mol Ther. 2021. PMID: 33388418 Free PMC article.

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