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Comment
. 2021 Mar 9;54(3):404-406.
doi: 10.1016/j.immuni.2021.02.016.

A neu(ronal) player joins the T regulatory game

Samantha B Larsen  1 , Shruti Naik  2
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A neu(ronal) player joins the T regulatory game

Samantha B Larsen et al. Immunity. .
Free article

Abstract

The enteric nervous system is surfacing as a key regulator of intestinal immunity and a liaison of host-commensal interactions. In this issue, Yan et al. identify neuronal interleukin-6 as a potent modulator of regulatory T (Treg) cells in the intestine. This neuroimmune dialog is further refined by commensal microbiota, which impact the enteric nervous system and consequently the intestinal Treg cell pool.

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