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Comment
. 2021 Mar 9;54(3):406-408.
doi: 10.1016/j.immuni.2021.02.017.

Erasing iatrogenic neoantigens from in vivo CRISPR screens

Fei Yi  1 , Christopher A Klebanoff  2
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Erasing iatrogenic neoantigens from in vivo CRISPR screens

Fei Yi et al. Immunity. .
Free article

Abstract

In vivo genetic screens using CRISPR-Cas9 are a powerful tool to resolve the molecular determinants of response and resistance to cancer immunotherapies; however, vector immunogenicity can introduce artifact. In this issue of Immunity, Dubrot et al. report a strategy to "erase" vector-associated neoantigens, enabling a more physiologic assessment of tumor-immune cell interactions in immunocompetent hosts.

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Conflict of interest statement

Declaration of interests F.Y. and C.A.K. hold provisional patents related to cell and gene therapy unrelated to the current work. C.A.K. is a scientific advisor to the following immunotherapy-focused companies: Achilles Therapeutics, Aleta Biotherapeutics, Bellicum Pharmaceuticals, Catamaran Biotherapeutics, Obsidian Therapeutics, Roche/Genentech, Pact Biopharma, T-Knife.

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