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Comment
. 2021 Mar 10;12(1):1551.
doi: 10.1038/s41467-021-21796-y.

Formal reply to "Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX"

Lars Feuerbach  1
Affiliations
Comment

Formal reply to "Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX"

Lars Feuerbach. Nat Commun. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1. Receiver operating characteristic analysis.
The curve shows the True positive rate (sensitivity) and the Fales positive rate (1 – specificity) for all possible thresholds on the ALT probability score (Sieverling et al.). The predicted class label is the C-circle status reported from Lee et al., while the red cross depicts the performance of the classifier proposed in the Matters Arising article for which classification results are reported for only one threshold.
See this image and copyright information in PMC

Comment on

References

    1. Sieverling L, et al. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat. Commun. 2020;11:1–13. doi: 10.1038/s41467-019-13824-9. - DOI - PMC - PubMed
    1. Feuerbach L, et al. TelomereHunter – in silico estimation of telomere content and composition from cancer genomes. BMC Bioinformatics. 2019;20:272. doi: 10.1186/s12859-019-2851-0. - DOI - PMC - PubMed
    1. Lee M, et al. Telomere sequence content can be used to determine ALT activity in tumours. Nucleic Acids Res. 2018;46:4903–4918. doi: 10.1093/nar/gky297. - DOI - PMC - PubMed
    1. Zhang J-M, Yadav T, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres through two distinct break-induced replication pathways. Cell Rep. 2019;26:955–968.e3. doi: 10.1016/j.celrep.2018.12.102. - DOI - PMC - PubMed
    1. Sing T, Sander O, Beerenwinkel N, Lengauer T. ROCR: visualizing classifier performance in R. Bioinformatics. 2005;21:3940–3941. doi: 10.1093/bioinformatics/bti623. - DOI - PubMed