Reply to Singh et al

Affiliations

¹ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. hechtmaj@mskcc.org.
² Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Free article

Comment

Jaclyn F Hechtman et al. Mod Pathol. 2021 May.

Free article

. 2021 May;34(5):1033-1034.

doi: 10.1038/s41379-021-00784-z. Epub 2021 Mar 10.

¹ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. hechtmaj@mskcc.org.
² Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

No abstract available

Comment on

Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes.
Hechtman JF, Rana S, Middha S, Stadler ZK, Latham A, Benayed R, Soslow R, Ladanyi M, Yaeger R, Zehir A, Shia J. Hechtman JF, et al. Mod Pathol. 2020 May;33(5):871-879. doi: 10.1038/s41379-019-0414-6. Epub 2019 Dec 19. Mod Pathol. 2020. PMID: 31857677 Free PMC article.
Interpretation of mismatch repair protein expression using obsolete criteria results in discrepancies with microsatellite instability and mutational testing results. Comment on Hechtman et al. Mod Pathol 2020; 33:871-879.
Singh N, Wong R, Tchrakian N, Allen SG, Clarke B, Gilks CB. Singh N, et al. Mod Pathol. 2021 May;34(5):1031-1032. doi: 10.1038/s41379-020-00680-y. Epub 2020 Sep 26. Mod Pathol. 2021. PMID: 32980858 No abstract available.

1. Singh N, Wong R, Tchrakian N, Allen SG, Clarke B, Gilks CB. Interpretation of mismatch repair protein expression using obsolete criteria results in discrepancies with microsatellite instability and mutational testing results. Comment on “Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes”. Mod Pathol. 2020;33:871–9. - DOI
1. Hechtman JF, Rana S, Middha S, Stadler ZK, Latham A, Benayed R, et al. Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes. Mod Pathol. 2020;33:871–9. - DOI
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1. Sari A, Pollett A, Eiriksson LR, Lumsden-Johanson B, Van de Laar E, Kazerouni H, et al. Interobserver agreement for mismatch repair protein immunohistochemistry in endometrial and nonserous, nonmucinous ovarian carcinomas. Am J Surg Pathol. 2019;43:591–600. - DOI
1. Chen W, Hampel H, Pearlman R, Jones D, Zhao W, Alsomali M, et al. Unexpected expression of mismatch repair protein is more commonly seen with pathogenic missense than with other mutations in Lynch syndrome. Hum Pathol. 2020;103:34–41. - DOI