Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;35(11):3272-3277.
doi: 10.1038/s41375-021-01199-0. Epub 2021 Mar 10.

Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group

Affiliations

Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group

Shinsuke Hirabayashi et al. Leukemia. 2021 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

C.G.M.: Research support from Loxo, Abbvie, Pfizer. Consulting and speaking fees from Amgen, Illumina. C-H Pui received consulting and speaker fees from Amgen, Erytech Phamra, and Servier. H.I. received a research grant from Servier.

Figures

Fig. 1
Fig. 1. Outcomes of patients with ZNF384 rearrangement-related ALL.
Outcomes of patients with ZNF384 rearrangement-related ALL according to partner gene and EP300-ZNF384 ALL compared with all other patients. Of note, outcome data were missing for 15 patients, and further 18 and 25 patients were excluded for selection bias and missing partner gene information, respectively.

References

    1. Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373:1541–52. doi: 10.1056/NEJMra1400972. - DOI - PubMed
    1. Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, et al. Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Nat. Genet. 2016;48:569–74. doi: 10.1038/ng.3535. - DOI - PubMed
    1. Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, et al. Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia. EBioMedicine. 2016;8:173–83. doi: 10.1016/j.ebiom.2016.04.038. - DOI - PMC - PubMed
    1. Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, et al. ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. Haematologica. 2017;102:118–29. doi: 10.3324/haematol.2016.151035. - DOI - PMC - PubMed
    1. Li JF, Dai YT, Lilljebjorn H, Shen SH, Cui BW, Bai L, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci USA. 2018;115:E11711–E20. doi: 10.1073/pnas.1814397115. - DOI - PMC - PubMed

Publication types

LinkOut - more resources