Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec;7(4):95-100.
doi: 10.1055/s-0040-1722303. Epub 2021 Feb 1.

Genetics of Dentofacial and Orthodontic Abnormalities

Praveen Kumar Neela  1 , Anjana Atteeri  1 , Pavan Kumar Mamillapalli  1 , Vasu Murthy Sesham  1 , Sreekanth Keesara  1 , Jaya Chandra  1 , Udayini Monica  1 , Vasavi Mohan  2
Affiliations
Review

Genetics of Dentofacial and Orthodontic Abnormalities

Praveen Kumar Neela et al. Glob Med Genet. 2020 Dec.

Abstract

The development of craniofacial complex and dental structures is a complex and delicate process guided by specific genetic mechanisms. Genetic and environmental factors can influence the execution of these mechanisms and result in abnormalities. An insight into the mechanisms and genes involved in the development of orofacial and dental structures has gradually gained by pedigree analysis of families and twin studies as well as experimental studies on vertebrate models. The development of novel treatment techniques depends on in-depth knowledge of the various molecular or cellular processes and genes involved in the development of the orofacial complex. This review article focuses on the role of genes in the development of nonsyndromic orofacial, dentofacial variations, malocclusions, excluding cleft lip palate, and the advancements in the field of molecular genetics and its application to obtain better treatment outcomes.

Keywords: dentofacial variations; genes; genetics; malocclusion; polymorphism.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None declared.

References

    1. Varma G, Harsha B, Palla S, Sravan S, Raju J, Rajavardhan K. Genetics in an orthodontic perspective. J Adv Clin Res Insights. 2019;18(06):3.
    1. Carlson D S. Evolving concepts of heredity and genetics in orthodontics. Am J Orthod Dentofacial Orthop. 2015;148:922–938. - PubMed
    1. Moreno Uribe L M, Miller S F. Genetics of the dentofacial variation in human malocclusion. Orthod Craniofac Res. 2015;18 01:91–99. - PMC - PubMed
    1. Xue F, Wong R W, Rabie A B. Genes, genetics, and Class III malocclusion. Orthod Craniofac Res. 2010;13:69–74. - PubMed
    1. Wolff G, Wienker T F, Sander H. On the genetics of mandibular prognathism: analysis of large European noble families. J Med Genet. 1993;30(02):112–116. - PMC - PubMed