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Review
. 2021 Jun;12(3):443-452.
doi: 10.1007/s41999-021-00479-3. Epub 2021 Mar 10.

Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences

Farhad Pazan  1 , Martin Wehling  2
Affiliations
Review

Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences

Farhad Pazan et al. Eur Geriatr Med. 2021 Jun.

Abstract

Background: The number of older adults has been constantly growing around the globe. Consequently, multimorbidity and related polypharmacy have become an increasing problem. In the absence of an accepted agreement on the definition of polypharmacy, data on its prevalence in various studies are not easily comparable. Besides, the evidence on the potential adverse clinical outcomes related to polypharmacy is limited though polypharmacy has been linked to numerous adverse clinical outcomes. This narrative review aims to find and summarize recent publications on definitions, epidemiology and clinical consequences of polypharmacy.

Methods: The MEDLINE database was used to identify recent publications on the definition, prevalence and clinical consequences of polypharmacy using their respective common terms and their variations. Systematic reviews and original studies published between 2015 and 2020 were included.

Results: One hundred and forty-three definitions of polypharmacy and associated terms were found. Most of them are numerical definitions. Its prevalence ranges from 4% among community-dwelling older people to over 96.5% in hospitalized patients. In addition, numerous adverse clinical outcomes were associated with polypharmacy.

Conclusion: The term polypharmacy is imprecise, and its definition is yet subject to an ongoing debate. The clinically oriented definitions of polypharmacy found in this review such as appropriate or necessary polypharmacy are more useful and relevant. Regardless of the definition, polypharmacy is highly prevalent in older adults, particularly in nursing home residents and hospitalized patients. Approaches to increase the appropriateness of polypharmacy can improve clinical outcomes in older adults.

Keywords: Health outcomes; Inappropriate prescribing; Multimorbidity; Older adults; Polypharmacy.

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Conflict of interest statement

MW was employed by AstraZeneca R&D, Mölndal, as director of discovery medicine (translational medicine) from 2003 to 2006, while on sabbatical leave from his professorship at the University of Heidelberg. Since returning to this position in January 2007, he has received lecturing and consulting fees from Sanofi-Aventis, Bayer, Berlin-Chemie, Boehringer Ingelheim, Aspen, Novartis, Takeda, Roche, Pfizer, Bristol-Myers, Daichii-Sankyo, Lilly, Otsuka, Novo-Nordisk, Shire and LEO Pharma. FP declares that he has no conflict of interest.

Figures

Fig. 1
Fig. 1
Prevalence of polypharmacy (defined as the concurrent use of five or more medications per day) in older adults across 17 European countries and Israel according to “wave 6” of the Survey of Health, Ageing, and Retirement in Europe (SHARE) [43] (Reprinted from Midão et al. [43], Copyright (2018), with permission from Elsevier. https://doi.org/10.1016/j.archger.2018.06.018)
See this image and copyright information in PMC

References

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