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. 2021 Mar 12;70(10):346-347.
doi: 10.15585/mmwr.mm7010e1.

First Identified Cases of SARS-CoV-2 Variant P.1 in the United States - Minnesota, January 2021

Melanie J Firestone, Alexandra J Lorentz, Stephanie Meyer, Xiong Wang, Kathryn Como-Sabetti, Sara Vetter, Kirk Smith, Stacy Holzbauer, Amanda Beaudoin, Jacob Garfin, Kristin Ehresmann, Richard Danila, Ruth Lynfield

First Identified Cases of SARS-CoV-2 Variant P.1 in the United States - Minnesota, January 2021

Melanie J Firestone et al. MMWR Morb Mortal Wkly Rep. .

Abstract

Since December 2020, the Minnesota Department of Health (MDH) Public Health Laboratory has been receiving 100 specimens per week (50 from each of two clinical partners) with low cycle threshold (Ct) values for routine surveillance for SARS-CoV-2, the virus that causes COVID-19. On January 25, 2021, MDH identified the SARS-CoV-2 variant P.1 in one specimen through this surveillance system using whole genome sequencing, representing the first identified case of this variant in the United States. The P.1 variant was first identified in travelers from Brazil during routine airport screening in Tokyo, Japan, in early January 2021 (1). This variant has been associated with increased transmissibility (2), and there are concerns that mutations in the spike protein receptor-binding domain might disrupt both vaccine-induced and natural immunity (3,4). As of February 28, 2021, a total of 10 P.1 cases had been identified in the United States, including the two cases described in this report, followed by one case each in Alaska, Florida, Maryland, and Oklahoma (5).

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Conflict of interest statement

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

References

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