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Comment
. 2021 Mar 10;29(3):311-312.
doi: 10.1016/j.chom.2021.02.014.

Local farming of gut fungi protects against dangerous imports

Darin L Wiesner  1
Affiliations
Comment

Local farming of gut fungi protects against dangerous imports

Darin L Wiesner. Cell Host Microbe. .

Abstract

Candida albicans is viewed as a harmless commensal in health and a dangerous parasite in disease. Recently in Cell, Doron et al. (2021) reveal that C. albicans in the gut additionally serves as a mutualist by provoking the immune system to generate far-reaching antibodies that defend against invasive fungal infections.

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Figures

FIGURE 1.
FIGURE 1.
Candida albicans is “Farmed” by Gut-resident Mononuclear Phagocytes Which Leads to Systemic Release of Protective Anti-fungal Antibodies. (A) C. albicans colonize the gut mucosa. (B) CX3CR1+ mononuclear phagocytes recognize gut fungi and signal via SYK and CARD9 to (C) promote the production of anti-C. albicans antibodies in the spleen. (D) anti-C. albicans antibodies enter blood circulation and defend against invasive candidiasis.
See this image and copyright information in PMC

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References

    1. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, et al. (2011). Enterotypes of the human gut microbiome. Nature 473, 174–180. - PMC - PubMed
    1. Bacher P, Hohnstein T, Beerbaum E, Rocker M, Blango MG, Kaufmann S, Rohmel J, Eschenhagen P, Grehn C, Seidel K, et al. (2019). Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell 176, 1340–1355 e1315. - PubMed
    1. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, and White TC (2012). Hidden killers: human fungal infections. Sci Transl Med 4, 165rv113. - PubMed
    1. Doron I, Leonardi I, Li XV, Fiers WD, Semon A, Bialt-DeCelie M, Migaud M, Gao IH, Lin WY, Kusakabe T, et al. (2021). Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies. Cell. - PMC - PubMed
    1. Glocker EO, Hennigs A, Nabavi M, Schaffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, et al. (2009). A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 361, 1727–1735. - PMC - PubMed

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