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Comment
. 2021 Mar 10;29(3):320-322.
doi: 10.1016/j.chom.2021.02.011.

Bariatric surgery stirs symbionts to counteract diabesity by CA(7)Sting a liver-generated bile acid into the mix

Jason M Ridlon  1
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Comment

Bariatric surgery stirs symbionts to counteract diabesity by CA(7)Sting a liver-generated bile acid into the mix

Jason M Ridlon. Cell Host Microbe. .
Free article

Abstract

Obesity and diabetes are major health challenges for the 21st century. Effective treatments affect nutrient signaling along the gut microbiome-bile acid axis. In this issue of Cell, Chaudhari et al. demonstrate that a gut microbial secondary bile acid stimulates hepatic synthesis of a sulfated bile acid with anti-diabetic properties.

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Conflict of interest statement

Declaration of interests The author has no competing interests to declare.

Comment on

  • A microbial metabolite remodels the gut-liver axis following bariatric surgery.
    Chaudhari SN, Luo JN, Harris DA, Aliakbarian H, Yao L, Paik D, Subramaniam R, Adhikari AA, Vernon AH, Kiliç A, Weiss ST, Huh JR, Sheu EG, Devlin AS. Chaudhari SN, et al. Cell Host Microbe. 2021 Mar 10;29(3):408-424.e7. doi: 10.1016/j.chom.2020.12.004. Epub 2021 Jan 11. Cell Host Microbe. 2021. PMID: 33434516 Free PMC article.

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