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Meta-Analysis
. 2021 Mar;49(3):300060521992956.
doi: 10.1177/0300060521992956.

PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis

Yijuan Xin  1 , Liu Yang  1 , Mingquan Su  1 , Xiaoli Cheng  1 , Lin Zhu  1 , Jiayun Liu  1
Affiliations
Meta-Analysis

PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis

Yijuan Xin et al. J Int Med Res. 2021 Mar.

Abstract

Objectives: To investigate the association between poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 Val762Ala and cancer risk in Asian populations, as published findings remain controversial.

Methods: The PubMed and EMBASE databases were searched, and references of identified studies and reviews were screened, to find relevant studies. Meta-analyses were performed to evaluate the association between PARP1 rs1136410 Val762Ala and cancer risk, reported as odds ratio (OR) and 95% confidence interval (CI).

Results: A total of 24 studies with 8 926 cases and 15 295 controls were included. Overall, a significant association was found between PARP1 rs1136410 Val762Ala and cancer risk in East Asians (homozygous: OR 1.19, 95% CI 1.06, 1.35; heterozygous: OR 1.10, 95% CI 1.04, 1.17; recessive: OR 1.13, 95% CI 1.02, 1.25; dominant: OR 1.13, 95% CI 1.06, 1.19; and allele comparison: OR 1.09, 95% CI 1.03, 1.15). Stratification analyses by race and cancer type revealed similar results for gastric cancer among the Chinese population.

Conclusion: The findings suggest that PARP1 rs1136410 Val762Ala may be significantly associated with an increased cancer risk in Asians, particularly the Chinese population.

Keywords: PARP1; Val762Ala; cancer; meta-analysis; risk.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow diagram showing selection of studies included in the current meta-analysis.
Figure 2.
Figure 2.
Stratification analysis by race showing odds ratios (ORs) and 95% confidence intervals (CIs) of the association between the poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 Val762Ala polymorphism and cancer risk in the allele comparison model.
Figure 3.
Figure 3.
Trial sequential analysis (TSA) of the poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 Val762Ala polymorphism under the dominant model.
Figure 4.
Figure 4.
Effect of poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 Val762Ala polymorphism on the expression of PARP1 extracted from the genotype-tissue expression (GTEx) database. The 762Val allele was significantly associated with higher levels of PARP1 expression in whole blood (P = 1.4 × 10−5).
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