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. 2021 Mar 11;11(1):5699.
doi: 10.1038/s41598-021-85267-6.

Association of early failure of arteriovenous fistula with mortality in hemodialysis patients

Yit-Sheung Yap  1   2 , Wen-Che Chi  3 , Cheng-Hao Lin  3 , Yi-Chun Liu  3 , Yi-Wen Wu  4
Affiliations

Association of early failure of arteriovenous fistula with mortality in hemodialysis patients

Yit-Sheung Yap et al. Sci Rep. .

Abstract

Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who underwent initial AVF surgery at a single institution. Demographic, clinical, biochemistry and AVF parameters were extracted from the electronic records, and the association between these variables and mortality was analyzed by Cox proportional hazards model. A total of 501 patients on hemodialysis (63.4 ± 12.7 years, 57.3% male) were included, and the median observation period was 3.66 years. In multivariate analysis, early failure of AVF (hazard ratio (95% confidence interval): 1.54 (1.06-2.24); p = 0.023) was associated with overall mortality but not cardiovascular mortality. Other identified predictors of overall mortality included older age, peripheral artery disease (PAD), cardiomegaly, higher white blood cell (WBC) count and corrected calcium level, and lower total cholesterol level, while predictors of cardiovascular mortality included older age, coronary artery disease (CAD), PAD and lower hemoglobin level. In conclusion, patients with early AVF failure were associated with increased risk of overall mortality.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
(a) Kaplan–Meier analyses of overall survival in patients with early failure and non-early failure of AVF. Log-rank p = 0.002. (b) Kaplan–Meier analyses of cardiovascular survival in patients with early failure and non-early failure of AVF. Log-rank p = 0.305.
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