Published Erratum
doi: 10.1038/s41586-021-03280-1.
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Alexander G Bick #
1
2
3
4
, Joshua S Weinstock
5
4
, Satish K Nandakumar
2
6
, Charles P Fulco
2
7
, Erik L Bao
2
6
8
, Seyedeh M Zekavat
2
9
, Mindy D Szeto
10
11
, Xiaotian Liao
2
6
, Matthew J Leventhal
2
, Joseph Nasser
2
, Kyle Chang
12
, Cecelia Laurie
13
, Bala Bharathi Burugula
14
, Christopher J Gibson
15
, Abhishek Niroula
2
15
, Amy E Lin
16
, Margaret A Taub
17
, Francois Aguet
2
, Kristin Ardlie
2
, Braxton D Mitchell
18
19
, Kathleen C Barnes
10
20
, Arden Moscati
21
, Myriam Fornage
22
23
, Susan Redline
3
24
25
, Bruce M Psaty
26
27
28
29
, Edwin K Silverman
3
30
, Scott T Weiss
3
30
, Nicholette D Palmer
31
, Ramachandran S Vasan
32
, Esteban G Burchard
33
34
, Sharon L R Kardia
35
, Jiang He
36
37
, Robert C Kaplan
38
39
, Nicholas L Smith
27
29
40
, Donna K Arnett
41
, David A Schwartz
42
, Adolfo Correa
43
, Mariza de Andrade
44
, Xiuqing Guo
45
, Barbara A Konkle
46
47
, Brian Custer
48
49
, Juan M Peralta
50
, Hongsheng Gui
51
, Deborah A Meyers
52
, Stephen T McGarvey
53
, Ida Yii-Der Chen
54
, M Benjamin Shoemaker
55
, Patricia A Peyser
35
, Jai G Broome
13
, Stephanie M Gogarten
13
, Fei Fei Wang
13
, Quenna Wong
13
, May E Montasser
18
, Michelle Daya
10
, Eimear E Kenny
56
, Kari E North
57
, Lenore J Launer
58
, Brian E Cade
24
59
, Joshua C Bis
26
, Michael H Cho
3
30
, Jessica Lasky-Su
3
30
, Donald W Bowden
31
, L Adrienne Cupples
60
, Angel C Y Mak
33
, Lewis C Becker
61
, Jennifer A Smith
35
62
, Tanika N Kelly
36
37
, Stella Aslibekyan
63
, Susan R Heckbert
27
29
, Hemant K Tiwari
64
, Ivana V Yang
42
, John A Heit
65
, Steven A Lubitz
2
3
66
, Jill M Johnsen
46
47
, Joanne E Curran
50
, Sally E Wenzel
67
, Daniel E Weeks
68
, Dabeeru C Rao
69
, Dawood Darbar
70
, Jee-Young Moon
38
, Russell P Tracy
71
, Erin J Buth
13
, Nicholas Rafaels
20
, Ruth J F Loos
21
72
, Peter Durda
71
, Yongmei Liu
73
, Lifang Hou
74
, Jiwon Lee
24
, Priyadarshini Kachroo
3
30
, Barry I Freedman
75
, Daniel Levy
76
77
, Lawrence F Bielak
35
, James E Hixson
78
, James S Floyd
26
27
47
, Eric A Whitsel
79
80
, Patrick T Ellinor
2
3
66
, Marguerite R Irvin
63
, Tasha E Fingerlin
81
, Laura M Raffield
82
, Sebastian M Armasu
44
, Marsha M Wheeler
83
, Ester C Sabino
84
, John Blangero
50
, L Keoki Williams
51
, Bruce D Levy
3
85
, Wayne Huey-Herng Sheu
86
, Dan M Roden
87
88
89
, Eric Boerwinkle
23
90
, JoAnn E Manson
3
91
92
, Rasika A Mathias
61
, Pinkal Desai
93
, Kent D Taylor
94
95
, Andrew D Johnson
76
77
; NHLBI Trans-Omics for Precision Medicine Consortium; Paul L Auer
96
, Charles Kooperberg
97
, Cathy C Laurie
13
, Thomas W Blackwell
5
, Albert V Smith
5
, Hongyu Zhao
98
99
, Ethan Lange
10
, Leslie Lange
10
, Stephen S Rich
100
, Jerome I Rotter
94
95
, James G Wilson
101
102
, Paul Scheet
12
, Jacob O Kitzman
14
103
, Eric S Lander
2
7
104
, Jesse M Engreitz
2
105
, Benjamin L Ebert
2
3
15
106
, Alexander P Reiner
27
97
, Siddhartha Jaiswal
107
, Gonçalo Abecasis
5
108
, Vijay G Sankaran
2
3
6
, Sekar Kathiresan
109
110
111
112
, Pradeep Natarajan
113
114
115
Collaborators,
Affiliations
Collaborators
-
NHLBI Trans-Omics for Precision Medicine Consortium:
Namiko Abe, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Dan Arking, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Dimitrios Avramopoulos, John Barnard, R Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Panagiotis Benos, Marcos Bezerra, Larry Bielak, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Karen Bunting, Carlos Bustamante, Jonathan Cardwell, Vincent Carey, Cara Carty, Richard Casaburi, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Elaine Cornell, Carolyn Crandall, James Crapo, Jeffrey Curtis, Coleen Damcott, Sayantan Das, Sean David, Colleen Davis, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Qing Duan, Ravi Duggirala, Susan Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Leslie Emery, Serpil Erzurum, Charles Farber, Matthew Flickinger, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Bruce Gelb, Xiaoqi Priscilla Geng, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Da-Wei Gong, Harald Goring, Sharon Graw, Daniel Grine, C Charles Gu, Yue Guan, Namrata Gupta, Jeff Haessler, Michael Hall, Daniel Harris, Nicola L Hawley, Ben Heavner, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao Agnes Hsiung, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Min A Jhun, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Shannon Kelly, Michael Kessler, Alyna Khan, Wonji Kim, Greg Kinney, Holly Kramer, Christoph Lange, Meryl LeBoff, Seunggeun Shawn Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Keng Han Lin, Xihong Lin, Simin Liu, Yu Liu, Kathryn Lunetta, James Luo, Michael Mahaney, Barry Make, Ani Manichaikul, Lauren Margolin, Lisa Martin, Susan Mathai, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Daniel McGoldrick, Caitlin McHugh, Hao Mei, Luisa Mestroni, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L Minster, Matt Moll, Courtney Montgomery, Solomon Musani, Stanford Mwasongwe, Josyf C Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Sergei Nekhai, Sarah C Nelson, Bonnie Neltner, Deborah Nickerson, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, David Paik, James Pankow, George Papanicolaou, Afshin Parsa, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S Phillips, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Laura Rasmussen-Torvik, Aakrosh Ratan, Robert Reed, Elizabeth Regan, Muagututi'a Sefuiva Reupena, Ken Rice, Carolina Roselli, Ingo Ruczinski, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Danish Saleheen, Shabnam Salimi, Steven Salzberg, Kevin Sandow, Christopher Scheller, Ellen Schmidt, Karen Schwander, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L Sherman, Amol Shetty, Aniket Shetty, Brian Silver, Josh Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Carole Sztalryd, Daniel Taliun, Hua Tang, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Heming Wang, Karol Watson, Bruce Weir, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, Carla Wilson, Joseph Wu, Huichun Xu, Lisa Yanek, Rongze Yang, Norann Zaghloul, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Degui Zhi, Xiang Zhou, Xiaofeng Zhu, Michael Zody, Sebastian Zoellner
Affiliations
- 1 Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
- 2 Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 3 Harvard Medical School, Boston, MA, USA.
- 4 Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 5 Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
- 6 Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
- 7 Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
- 8 Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.
- 9 Yale School of Medicine, New Haven, CT, USA.
- 10 Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- 11 Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- 12 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
- 13 Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 14 Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
- 15 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
- 16 Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 17 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
- 18 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
- 19 Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
- 20 Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
- 21 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 22 Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
- 23 Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
- 24 Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 25 Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
- 26 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
- 27 Department of Epidemiology, University of Washington, Seattle, WA, USA.
- 28 Department of Health Services, University of Washington, Seattle, WA, USA.
- 29 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
- 30 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 31 Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
- 32 Departments of Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.
- 33 Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
- 34 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, USA.
- 35 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
- 36 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
- 37 Tulane University Translational Science Institute, New Orleans, LA, USA.
- 38 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
- 39 Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
- 40 Seattle Epidemiologic Information and Research Center, Department of Veterans Affairs, Office of Research and Development, Seattle, WA, USA.
- 41 College of Public Health, University of Kentucky, Lexington, KY, USA.
- 42 Department of Medicine, University of Colorado, Aurora, CO, USA.
- 43 Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
- 44 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
- 45 Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
- 46 Bloodworks Northwest, Seattle, WA, USA.
- 47 Department of Medicine, University of Washington, Seattle, WA, USA.
- 48 Vitalant Research Institute, San Francisco, CA, USA.
- 49 Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
- 50 Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
- 51 Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
- 52 Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
- 53 Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.
- 54 Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
- 55 Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 56 Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 57 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
- 58 Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.
- 59 Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.
- 60 Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA.
- 61 GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
- 62 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
- 63 Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
- 64 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
- 65 Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
- 66 Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
- 67 Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
- 68 Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
- 69 Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
- 70 Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
- 71 Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
- 72 Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 73 Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
- 74 Department of Preventive Medicine, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
- 75 Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
- 76 Framingham Heart Study, Framingham, MA, USA.
- 77 Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- 78 Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
- 79 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
- 80 Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
- 81 Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA.
- 82 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- 83 Department of Genome Science, University of Washington, Seattle, WA, USA.
- 84 Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
- 85 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 86 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
- 87 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 88 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 89 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 90 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
- 91 Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 92 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
- 93 Department of Medicine, Weill Cornell Medical School, New York, NY, USA.
- 94 Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
- 95 Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
- 96 Joseph J. Zilber School of Public Health, University of WisconsinMilwaukee, Milwaukee, WI, USA.
- 97 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 98 Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
- 99 Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.
- 100 Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
- 101 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
- 102 Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
- 103 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
- 104 Department of Biology, MIT, Cambridge, MA, USA.
- 105 Harvard Society of Fellows, Harvard University, Cambridge, MA, USA.
- 106 Howard Hughes Medical Institute, Boston, MA, USA.
- 107 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
- 108 Regeneron Pharmaceuticals, Tarrytown, NY, USA.
- 109 Broad Institute of MIT and Harvard, Cambridge, MA, USA. sekar@broadinstitute.org.
- 110 Harvard Medical School, Boston, MA, USA. sekar@broadinstitute.org.
- 111 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. sekar@broadinstitute.org.
- 112 Verve Therapeutics, Cambridge, MA, USA. sekar@broadinstitute.org.
- 113 Broad Institute of MIT and Harvard, Cambridge, MA, USA. pradeep@broadinstitute.org.
- 114 Harvard Medical School, Boston, MA, USA. pradeep@broadinstitute.org.
- 115 Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pradeep@broadinstitute.org.
# Contributed equally.
- PMID: 33707633
- DOI: 10.1038/s41586-021-03280-1
Item in Clipboard
Published Erratum
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Alexander G Bick et al.
Nature.
2021 Mar.
Display options
Format
doi: 10.1038/s41586-021-03280-1.
Authors
Alexander G Bick #
1
2
3
4
, Joshua S Weinstock
5
4
, Satish K Nandakumar
2
6
, Charles P Fulco
2
7
, Erik L Bao
2
6
8
, Seyedeh M Zekavat
2
9
, Mindy D Szeto
10
11
, Xiaotian Liao
2
6
, Matthew J Leventhal
2
, Joseph Nasser
2
, Kyle Chang
12
, Cecelia Laurie
13
, Bala Bharathi Burugula
14
, Christopher J Gibson
15
, Abhishek Niroula
2
15
, Amy E Lin
16
, Margaret A Taub
17
, Francois Aguet
2
, Kristin Ardlie
2
, Braxton D Mitchell
18
19
, Kathleen C Barnes
10
20
, Arden Moscati
21
, Myriam Fornage
22
23
, Susan Redline
3
24
25
, Bruce M Psaty
26
27
28
29
, Edwin K Silverman
3
30
, Scott T Weiss
3
30
, Nicholette D Palmer
31
, Ramachandran S Vasan
32
, Esteban G Burchard
33
34
, Sharon L R Kardia
35
, Jiang He
36
37
, Robert C Kaplan
38
39
, Nicholas L Smith
27
29
40
, Donna K Arnett
41
, David A Schwartz
42
, Adolfo Correa
43
, Mariza de Andrade
44
, Xiuqing Guo
45
, Barbara A Konkle
46
47
, Brian Custer
48
49
, Juan M Peralta
50
, Hongsheng Gui
51
, Deborah A Meyers
52
, Stephen T McGarvey
53
, Ida Yii-Der Chen
54
, M Benjamin Shoemaker
55
, Patricia A Peyser
35
, Jai G Broome
13
, Stephanie M Gogarten
13
, Fei Fei Wang
13
, Quenna Wong
13
, May E Montasser
18
, Michelle Daya
10
, Eimear E Kenny
56
, Kari E North
57
, Lenore J Launer
58
, Brian E Cade
24
59
, Joshua C Bis
26
, Michael H Cho
3
30
, Jessica Lasky-Su
3
30
, Donald W Bowden
31
, L Adrienne Cupples
60
, Angel C Y Mak
33
, Lewis C Becker
61
, Jennifer A Smith
35
62
, Tanika N Kelly
36
37
, Stella Aslibekyan
63
, Susan R Heckbert
27
29
, Hemant K Tiwari
64
, Ivana V Yang
42
, John A Heit
65
, Steven A Lubitz
2
3
66
, Jill M Johnsen
46
47
, Joanne E Curran
50
, Sally E Wenzel
67
, Daniel E Weeks
68
, Dabeeru C Rao
69
, Dawood Darbar
70
, Jee-Young Moon
38
, Russell P Tracy
71
, Erin J Buth
13
, Nicholas Rafaels
20
, Ruth J F Loos
21
72
, Peter Durda
71
, Yongmei Liu
73
, Lifang Hou
74
, Jiwon Lee
24
, Priyadarshini Kachroo
3
30
, Barry I Freedman
75
, Daniel Levy
76
77
, Lawrence F Bielak
35
, James E Hixson
78
, James S Floyd
26
27
47
, Eric A Whitsel
79
80
, Patrick T Ellinor
2
3
66
, Marguerite R Irvin
63
, Tasha E Fingerlin
81
, Laura M Raffield
82
, Sebastian M Armasu
44
, Marsha M Wheeler
83
, Ester C Sabino
84
, John Blangero
50
, L Keoki Williams
51
, Bruce D Levy
3
85
, Wayne Huey-Herng Sheu
86
, Dan M Roden
87
88
89
, Eric Boerwinkle
23
90
, JoAnn E Manson
3
91
92
, Rasika A Mathias
61
, Pinkal Desai
93
, Kent D Taylor
94
95
, Andrew D Johnson
76
77
; NHLBI Trans-Omics for Precision Medicine Consortium; Paul L Auer
96
, Charles Kooperberg
97
, Cathy C Laurie
13
, Thomas W Blackwell
5
, Albert V Smith
5
, Hongyu Zhao
98
99
, Ethan Lange
10
, Leslie Lange
10
, Stephen S Rich
100
, Jerome I Rotter
94
95
, James G Wilson
101
102
, Paul Scheet
12
, Jacob O Kitzman
14
103
, Eric S Lander
2
7
104
, Jesse M Engreitz
2
105
, Benjamin L Ebert
2
3
15
106
, Alexander P Reiner
27
97
, Siddhartha Jaiswal
107
, Gonçalo Abecasis
5
108
, Vijay G Sankaran
2
3
6
, Sekar Kathiresan
109
110
111
112
, Pradeep Natarajan
113
114
115
Collaborators
-
NHLBI Trans-Omics for Precision Medicine Consortium:
Namiko Abe, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Dan Arking, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Dimitrios Avramopoulos, John Barnard, R Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Panagiotis Benos, Marcos Bezerra, Larry Bielak, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Karen Bunting, Carlos Bustamante, Jonathan Cardwell, Vincent Carey, Cara Carty, Richard Casaburi, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Elaine Cornell, Carolyn Crandall, James Crapo, Jeffrey Curtis, Coleen Damcott, Sayantan Das, Sean David, Colleen Davis, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Qing Duan, Ravi Duggirala, Susan Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Leslie Emery, Serpil Erzurum, Charles Farber, Matthew Flickinger, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Bruce Gelb, Xiaoqi Priscilla Geng, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Da-Wei Gong, Harald Goring, Sharon Graw, Daniel Grine, C Charles Gu, Yue Guan, Namrata Gupta, Jeff Haessler, Michael Hall, Daniel Harris, Nicola L Hawley, Ben Heavner, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao Agnes Hsiung, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Min A Jhun, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Shannon Kelly, Michael Kessler, Alyna Khan, Wonji Kim, Greg Kinney, Holly Kramer, Christoph Lange, Meryl LeBoff, Seunggeun Shawn Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Keng Han Lin, Xihong Lin, Simin Liu, Yu Liu, Kathryn Lunetta, James Luo, Michael Mahaney, Barry Make, Ani Manichaikul, Lauren Margolin, Lisa Martin, Susan Mathai, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Daniel McGoldrick, Caitlin McHugh, Hao Mei, Luisa Mestroni, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L Minster, Matt Moll, Courtney Montgomery, Solomon Musani, Stanford Mwasongwe, Josyf C Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Sergei Nekhai, Sarah C Nelson, Bonnie Neltner, Deborah Nickerson, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, David Paik, James Pankow, George Papanicolaou, Afshin Parsa, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S Phillips, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Laura Rasmussen-Torvik, Aakrosh Ratan, Robert Reed, Elizabeth Regan, Muagututi'a Sefuiva Reupena, Ken Rice, Carolina Roselli, Ingo Ruczinski, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Danish Saleheen, Shabnam Salimi, Steven Salzberg, Kevin Sandow, Christopher Scheller, Ellen Schmidt, Karen Schwander, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L Sherman, Amol Shetty, Aniket Shetty, Brian Silver, Josh Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Carole Sztalryd, Daniel Taliun, Hua Tang, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Heming Wang, Karol Watson, Bruce Weir, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, Carla Wilson, Joseph Wu, Huichun Xu, Lisa Yanek, Rongze Yang, Norann Zaghloul, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Degui Zhi, Xiang Zhou, Xiaofeng Zhu, Michael Zody, Sebastian Zoellner
Affiliations
- 1 Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
- 2 Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 3 Harvard Medical School, Boston, MA, USA.
- 4 Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 5 Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
- 6 Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
- 7 Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
- 8 Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.
- 9 Yale School of Medicine, New Haven, CT, USA.
- 10 Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- 11 Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- 12 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
- 13 Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 14 Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
- 15 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
- 16 Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 17 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
- 18 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
- 19 Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
- 20 Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
- 21 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 22 Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
- 23 Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
- 24 Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 25 Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
- 26 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
- 27 Department of Epidemiology, University of Washington, Seattle, WA, USA.
- 28 Department of Health Services, University of Washington, Seattle, WA, USA.
- 29 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
- 30 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 31 Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
- 32 Departments of Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.
- 33 Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
- 34 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, USA.
- 35 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
- 36 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
- 37 Tulane University Translational Science Institute, New Orleans, LA, USA.
- 38 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
- 39 Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
- 40 Seattle Epidemiologic Information and Research Center, Department of Veterans Affairs, Office of Research and Development, Seattle, WA, USA.
- 41 College of Public Health, University of Kentucky, Lexington, KY, USA.
- 42 Department of Medicine, University of Colorado, Aurora, CO, USA.
- 43 Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
- 44 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
- 45 Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
- 46 Bloodworks Northwest, Seattle, WA, USA.
- 47 Department of Medicine, University of Washington, Seattle, WA, USA.
- 48 Vitalant Research Institute, San Francisco, CA, USA.
- 49 Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
- 50 Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
- 51 Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
- 52 Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
- 53 Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.
- 54 Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
- 55 Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 56 Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 57 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
- 58 Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.
- 59 Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.
- 60 Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA.
- 61 GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
- 62 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
- 63 Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
- 64 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
- 65 Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
- 66 Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
- 67 Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
- 68 Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
- 69 Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
- 70 Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
- 71 Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
- 72 Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 73 Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
- 74 Department of Preventive Medicine, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
- 75 Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
- 76 Framingham Heart Study, Framingham, MA, USA.
- 77 Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- 78 Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
- 79 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
- 80 Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
- 81 Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA.
- 82 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- 83 Department of Genome Science, University of Washington, Seattle, WA, USA.
- 84 Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
- 85 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 86 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
- 87 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 88 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 89 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 90 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
- 91 Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 92 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
- 93 Department of Medicine, Weill Cornell Medical School, New York, NY, USA.
- 94 Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
- 95 Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
- 96 Joseph J. Zilber School of Public Health, University of WisconsinMilwaukee, Milwaukee, WI, USA.
- 97 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 98 Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
- 99 Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.
- 100 Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
- 101 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
- 102 Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
- 103 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
- 104 Department of Biology, MIT, Cambridge, MA, USA.
- 105 Harvard Society of Fellows, Harvard University, Cambridge, MA, USA.
- 106 Howard Hughes Medical Institute, Boston, MA, USA.
- 107 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
- 108 Regeneron Pharmaceuticals, Tarrytown, NY, USA.
- 109 Broad Institute of MIT and Harvard, Cambridge, MA, USA. sekar@broadinstitute.org.
- 110 Harvard Medical School, Boston, MA, USA. sekar@broadinstitute.org.
- 111 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. sekar@broadinstitute.org.
- 112 Verve Therapeutics, Cambridge, MA, USA. sekar@broadinstitute.org.
- 113 Broad Institute of MIT and Harvard, Cambridge, MA, USA. pradeep@broadinstitute.org.
- 114 Harvard Medical School, Boston, MA, USA. pradeep@broadinstitute.org.
- 115 Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pradeep@broadinstitute.org.
# Contributed equally.
- PMID: 33707633
- DOI: 10.1038/s41586-021-03280-1
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Inherited causes of clonal haematopoiesis in 97,691 whole genomes.Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD; NHLBI Tran… See abstract for full author list ➔ Bick AG, et al. Nature. 2020 Oct;586(7831):763-768. doi: 10.1038/s41586-020-2819-2. Epub 2020 Oct 14. Nature. 2020. PMID: 33057201 Free PMC article.
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