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Observational Study
. 2022 Feb;36(2):457-462.
doi: 10.1038/s41433-021-01452-x. Epub 2021 Mar 11.

Visual functions affecting stereopsis in patients with branch retinal vein occlusion

Shohei Morikawa  1 , Fumiki Okamoto  2 , Tomoya Murakami  1 , Yoshimi Sugiura  1 , Takahiro Hiraoka  1 , Tetsuro Oshika  1
Affiliations
Observational Study

Visual functions affecting stereopsis in patients with branch retinal vein occlusion

Shohei Morikawa et al. Eye (Lond). 2022 Feb.

Abstract

Purpose: To quantify stereopsis and other visual functions in patients with unilateral branch retinal vein occlusion (BRVO) and to investigate vision-related parameters that affect stereopsis.

Design: Prospective observational study.

Subjects: Forty-five patients undergoing intravitreal ranibizumab (IVR) treatment for unilateral BRVO.

Methods: We examined stereopsis using the Titmus stereo test (TST) and TNO stereotest (TNO), best corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia and degree of aniseikonia before and 6 months after IVR.

Main outcome measures: Visual functions that affect stereopsis.

Results: Baseline stereopsis in patients with BRVO was 2.7 ± 0.6 (range, 1.6-3.5) in the TST and 2.8 ± 0.5 (range, 1.8-3.3) in TNO. TST and TNO scores were significantly correlated with BCVA and letter contrast sensitivity at baseline (P < 0.001) but not with other visual functions. IVR treatment significantly improved stereopsis, BCVA, and letter contrast sensitivity. After treatment, TST scores were significantly correlated with BCVA (P < 0.001), letter contrast sensitivity (P < 0.001), and aniseikonia (P < 0.01). TNO scores were significantly correlated with BCVA (P < 0.01) and letter contrast sensitivity (P < 0.01). TST and TNO scores after treatment were significantly correlated with BCVA at baseline (P < 0.01 for both).

Conclusions: Deterioration of stereopsis in patients with BRVO was associated with changes in visual acuity and contrast sensitivity after treatment. Initial visual acuity is a prognostic factor for posttreatment stereopsis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Relationship between best corrected visual acuity at baseline and Stereopsis after treatment in patients with branch retinal vein occlusion.
A Titmus stereo test score after treatment was correlated with best-corrected visual acuity at baseline (Spearman rank correlation test). B TNO stereotest score after treatment was correlated with best-corrected visual acuity at baseline (Spearman rank correlation test).
See this image and copyright information in PMC

References

    1. Rabena MD, Pieramici DJ, Castellarin AA, Nasir MA, Avery RL. Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion. Retina. 2007;27:419–25. doi: 10.1097/IAE.0b013e318030e77e. - DOI - PubMed
    1. Morikawa S, Okamoto F, Sugiura Y, Murakami T, Hiraoka T, Oshika T. Stereopsis after intravitreal ranibizumab injections for branch retinal vein occlusion. Ophthalmol Retin. 2019;3:777–83. doi: 10.1016/j.oret.2019.04.003. - DOI - PubMed
    1. Noma H, Funatsu H, Harino S, Nagaoka T, Mimura T, Hori S. Influence of macular microcirculation and retinal thickness on visual acuity in patients with branch retinal vein occlusion and macular edema. Jpn J Ophthalmol. 2010;54:430–4. doi: 10.1007/s10384-010-0834-9. - DOI - PubMed
    1. Sugiura Y, Okamoto F, Murakami T, Morikawa S, Hiraoka T, Oshika T. Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occlusion. Jpn J Ophthalmol. 2020;64:497–505. doi: 10.1007/s10384-020-00758-9. - DOI - PubMed
    1. Preti RC, Ramirez LM, Pimentel SL, Motta AA, Machado CG, Monteiro ML. Single intravitreal bevacizumab injection effects on contrast sensitivity in macular edema from branch retinal vein occlusion. Arq Bras Oftalmol. 2012;75:29–32. doi: 10.1590/S0004-27492012000100006. - DOI - PubMed

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