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Case Reports
. 2020 Sep-Oct;30(5):334-336.
doi: 10.4103/ijn.IJN_75_19. Epub 2020 Aug 27.

Naproxen Induced Acute Interstitial Nephritis with Renal Cortical Necrosis

Christine M Jane  1 , V Narayanan Unni  1 , K Vinod Kumar  1 , Nanda Kachare  2 , Bipi Prasannan  1 , Jojo K Pullockara  1
Affiliations
Case Reports

Naproxen Induced Acute Interstitial Nephritis with Renal Cortical Necrosis

Christine M Jane et al. Indian J Nephrol. 2020 Sep-Oct.

Abstract

Drug induced acute interstitial nephritis is an idiosyncratic reaction following a drug exposure. The commonest drugs implicated are nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics and proton pump inhibitors. Renal cortical necrosis is a rare cause of acute kidney injury caused by severe and sustained vasoconstriction of small renal vessels. There is a change in the epidemiology of acute kidney injury especially in developing countries where drug induced acute kidney injury is becoming increasingly common. Naproxen is known to cause renal failure by renal papillary necrosis, tubular damage and acute interstitial nephritis. We present a case of Naproxen induced acute interstitial nephritis with acute cortical necrosis. To the best of our knowledge this is the first documented case of Naproxen induced renal cortical necrosis.

Keywords: NSAIDs; Naproxen; Renal cortical necrosis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Renal biopsy with patchy cortical necrosis (arrow) (a, H and E, 40X); with dense interstitial infiltrates of eosinophils and lymphocytes (arrow) (b, H and E,40X)
See this image and copyright information in PMC

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