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Review
. 2021 Jan;37(1):10-20.
doi: 10.1007/s12288-020-01295-8. Epub 2020 Jun 3.

Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL)

Manisha Agarwal  1 , Rachna Seth  2 , Tathagata Chatterjee  1
Affiliations
Review

Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL)

Manisha Agarwal et al. Indian J Hematol Blood Transfus. 2021 Jan.

Abstract

B cell lineage acute lymphoblastic leukemia is the most common leukemia occurring in children and young adults and is the leading cause of cancer related deaths. The 5 year overall survival outcome in children with B-ALL has improved significantly in the last few decades. In the past, the discovery of various genetic alterations and targeted therapy have played a major role in decreasing disease-related deaths. In addition, numerous advances in the pathogenesis of B-ALL have been found which have provided better understanding of the genes involved in disease biology with respect to diagnostic and prognostic implications. Present review will summarize current understanding of risk stratification, genetic factors including cytogenetics in diagnosis and prognosis of B-ALL.

Keywords: Targeted therapy; Copy number alterations; Cytogenetic risk groups.

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Figures

Fig. 1
Fig. 1
Approach to molecular diagnosis in B-ALL (continuous line represents definite responses; dotted lines represent response requiring further investigations
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