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Review
. 2021 Mar 5:14:1727-1735.
doi: 10.2147/OTT.S297332. eCollection 2021.

Biological Function of HYOU1 in Tumors and Other Diseases

Shan Rao  1 , Linda Oyang  1 , Jiaxin Liang  1 , Pin Yi  1 , Yaqian Han  1 , Xia Luo  1 , Longzheng Xia  1 , Jinguan Lin  1 , Shiming Tan  1 , Jiaqi Hu  1 , Hui Wang  1 , Lu Tang  1   2 , Qing Pan  1   2 , Yanyan Tang  1 , Yujuan Zhou  1 , Qianjin Liao  1
Affiliations
Review

Biological Function of HYOU1 in Tumors and Other Diseases

Shan Rao et al. Onco Targets Ther. .

Abstract

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.

Keywords: HYOU1; anti-tumor immunity; endoplasmic reticulum; tumor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
The role model of intracellular HYOU1 in tumor development. The endoplasmic reticulum stress response up-regulates the expression of HYOU1 through the PERK-eIF2α-ATF4 pathway and the active form of the p50-ATF6 pathway, and inhibit the expression of CHOP and reduce apoptosis. HYOU1 promotes tumor angiogenesis by promoting VEGF secretion. HYOU1 promotes cell proliferation, invasion and migration by up-regulating the expression of p-PI3K and p-Akt. HYOU1 reduces apoptosis by down-regulating the expression of IFN-α and IFN-β.
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