Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jul 29:36:228.
doi: 10.11604/pamj.2020.36.228.21487. eCollection 2020.

Verrucous sarcoidosis: a diagnosis to keep in mind

Nadia Nabli  1 , Rima Gammoudi  1 , Amina Aounallah  1 , Badreddine Sriha  2 , Colandane Belajouza  1 , Mohamed Denguezli  1
Affiliations
Case Reports

Verrucous sarcoidosis: a diagnosis to keep in mind

Nadia Nabli et al. Pan Afr Med J. .

Abstract

Skin manifestations of sarcoidosis occur in up to 30% of cases, and may be the sentinel sign of the disease, with the skin being sometimes exclusively affected. While this may facilitate an early dermatologic diagnosis, heterogeneity in the cutaneous morphologies of sarcoidosis complicates recognition and affirms its reputation as a "great imitator". Here, we present a case of a verrucous version of sarcoidosis that may be misdiagnosed because it can mimic other inflammatory and neoplastic skin disorders. Although it is a rare variant, its presence should alert clinicians to the likelihood of systemic involvement of cutaneous sarcoidosis.

Keywords: Verrucous sarcoidosis; perineum; pulmonary sarcoidosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
A, B) verrucous plaques with deep fissures on the gluteal region, perineum and inner thighs; (C) close-up view of the verrucous lesion on groin area
Figure 2
Figure 2
histopathology of verrucous sarcoidosis; A) epidermis shows papillomatous architecture with hyperkeratosis and acanthosis (hematoxylin-eosin stain; original magnification x 40); B) sarcoidal granuloma with multinucleated giant cells surrounded by a sprinkling of lymphocytes, is noted in the dermis (hematoxylin-eosin stain; original magnification x 200)
See this image and copyright information in PMC

References

    1. Tchernev G, Patterson JW, Nenoff P, Horn LC. Sarcoidosis of the skin a dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition. J Eur Acad Dermatol Venereol. 2010;24(2):125–37. - PubMed
    1. Stockman DL, Rosenberg J, Bengana C, Suster S, Plaza JA. Verrucous cutaneous sarcoidosis: case report and review of this unusual variant of cutaneous sarcoidosis. Am J Dermatopathol. 2013;35(2):273–6. - PubMed
    1. Koch LH, Mahoney MH, Pariser RJ. Cutaneous sarcoidosis manifesting as extensive verrucous plaques. Int J Dermatol. 2010 Dec;49(12):1458–9. - PubMed
    1. Noparstak M, McDaniel B, King J, Brodell RT, Rady P, Killipara R, et al. Verrucous sarcoidosis associated with human papillomavirus infection: A case report. JAAD Case Rep. 2015;1(5):247–50. - PMC - PubMed
    1. García-Colmenero L, Sánchez-Schmidt JM, Barranco C, Pujol RM. The natural history of cutaneous sarcoidosis, Clinical spectrum and histological analysis of 40 cases. Int J Dermatol. 2019;58(2):178–184. - PubMed

Publication types