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Editorial
. 2020 Nov;10(1):e12032.
doi: 10.1002/jev2.12032. Epub 2020 Nov 29.

Hitting the Bullseye: Are extracellular vesicles on target?

Nicole Noren Hooten  1 , María Yáñez-Mó  2 , Rachel DeRita  3 , Ashley Russell  4 , Peter Quesenberry  5 , Bharat Ramratnam  6 , Paul D Robbins  7 , Dolores Di Vizio  8 , Sicheng Wen  5 , Kenneth W Witwer  4   9 , Lucia R Languino  3
Affiliations
Editorial

Hitting the Bullseye: Are extracellular vesicles on target?

Nicole Noren Hooten et al. J Extracell Vesicles. 2020 Nov.
No abstract available

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Current strategies for engineering EVs. (a) Cells can be transfected with plasmids containing targeting receptors and/or peptides. EVs bearing the targeting receptor and/or peptide can then be isolated from these cells. Cells can also be treated with a drug that then is encapsulated into an EV for delivery. In addition, cells can be both transfected with targeting plasmid and treated with a therapeutic drug for EV delivery. (b) EVs can be electroporated (or equivalent technique) with a drug of interest or RNA molecule (siRNA, miRNA or shRNA) for incorporation into the EV. This figure was created with help from Nicolas Fernandez.
FIGURE 2
FIGURE 2
Strategies for EV targeting to specific cells or organs. Examples of targeting strategies for delivery of EVs to target organs/cells. PDGFR: platelet derived growth factor receptor; LAMP2: Lysosomal Associated Membrane Protein 2. This figure was created with BioRender.com.
See this image and copyright information in PMC

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