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. 2021 Feb;9(6):321-323.
doi: 10.1159/000511707. Epub 2020 Oct 30.

Subacute Thyroiditis in COVID-19 Patients

Saeed Sohrabpour  1 , Farrokh Heidari  1 , Ebrahim Karimi  1 , Reza Ansari  1 , Ardavan Tajdini  1 , Firouzeh Heidari  1
Affiliations

Subacute Thyroiditis in COVID-19 Patients

Saeed Sohrabpour et al. Eur Thyroid J. 2021 Feb.

Abstract

Introduction: Since December 2019, novel coronavirus (COVID-19) infection has been identified as the cause of an outbreak of respiratory illness in Wuhan, China. The classic presentation of COVID-19 infection was described as fever, myalgia, cough, and fatigue. Whether coronavirus can directly attack the endocrine glands is unclear.

Objective: Post-viral subacute thyroiditis (SAT, de Quervain thyroiditis) has been reported following other viral infection. A limited number of SAT after COVID-19 infection have been reported up to now.

Methods: Here, we reported 6 patients with SAT and positive COVID-19 serology tests. Demographic, clinical, biochemical, and imaging data were presented.

Results: In this study, 6 patients (4 women and 2 men) with clinician manifestations and physical examination in favor of SAT were described. Cervical ultrasonography showed bilateral hypoechoic areas in the thyroid gland which was suggestive of SAT. Elevated C-reactive protein, erythrocyte sedimentation rate, free thyroxine, free tri-iodothyronine, and undetectable thyrotropin were found in laboratory evaluations. Both IgM and IgG were positive for COVID-19 infection, but the PCR tests were negative in all patients. Patients had history of working in a COVID center and/or family member hospitalized due to COVID-19 pneumonia. Patients were followed up for 1 month and were treated effectively with steroids.

Conclusion: This report may help physicians to identify lesser-known manifestations and complications of COVID-19. Early diagnosis of COVID-19 infection results in the prevention of further transmission.

Keywords: 2019-nCoV; COVID-19; Coronavirus; De Quervain thyroiditis; Subacute thyroiditis.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

References

    1. Patel A, Jernigan DB. Initial public Health response and interim clinical guidance for the 2019 novel coronavirus outbreak: United States, December 31, 2019–February 4, 2020. MMWR Morb Mortal Wkly Rep. 2020 Feb 7;69((5)):140–6. - PMC - PubMed
    1. Agrawal S, Goel AD, Gupta N. Emerging prophylaxis strategies against COVID-19. Monaldi Arch Chest Dis. 2020 Mar 30;90((1)) - PubMed
    1. Sun P, Qie S, Liu Z, Ren J, Xi J. Clinical characteristics of 5732 patients with 2019-nCoV infection. 2020.
    1. Ansari R, Gheitani M, Heidari F, Heidari F. Oral cavity lesions as a manifestation of the novel virus (COVID‐19): a letter‐to‐editor. Oral Diseases. 2020 - PubMed
    1. Heidari F, Karimi E, Firouzifar M, Khamushian P, Ansari R, Mohammadi Ardehali M, et al. Anosmia as a prominent symptom of COVID-19 infection. Rhin. 2020;58((3)):302–3. - PubMed