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Case Reports
. 2021 Jan 28;11(1):16-25.
doi: 10.1159/000510840. eCollection 2021 Jan-Apr.

Collapsing FSGS with Concurrent Class 2 and 3 Lupus Nephritis: A Case Report and Review of the Literature

Aimen Vanood  1 , Ryan Owen  1   2 , Marina Maraskine  1   2 , Ariyon Schreiber  1 , Rajesh Pokharel  1   2 , Lisa Cohen  1   2   3
Affiliations
Case Reports

Collapsing FSGS with Concurrent Class 2 and 3 Lupus Nephritis: A Case Report and Review of the Literature

Aimen Vanood et al. Case Rep Nephrol Dial. .

Abstract

Lupus nephritis (LN) and the collapsing variant of focal segmental glomerulosclerosis (cFSGS) are separate histologic diagnoses that are generally thought to have separate etiologies. We describe the presentation of a 20-year-old African American female with advanced renal failure (creatinine 7.16 mg/dL), nephrotic-range proteinuria, and a 30-pound weight loss. Renal biopsy demonstrated class 2 and 3 LN as well as cFSGS. A review of the current literature demonstrates that the dual diagnosis of LN and cFSGS may not be as rare as previously understood. Whether the presence of one of these pathophysiologic processes predisposes a patient to the development of the other, or whether genetic variation increases the risk for development of both conditions, remains unclear. Currently there is no standard therapy to manage these patients, and overall renal prognosis is poor.

Keywords: Chronic kidney disease; ESRD; Focal segmental glomerulosclerosis; Lupus nephritis; Proteinuria.

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Conflict of interest statement

The authors declare that there is no conflict of interest to disclose regarding the publication of this article. The authors declare no competing financial interests.

Figures

Fig. 1
Fig. 1
Light microscopy with periodic acid-Schiff staining demonstrating a collapsed glomerular tuft (arrows), epithelial cell hyperplasia, moderate interstitial fibrosis, and tubular atrophy.
Fig. 2
Fig. 2
Electron microscopy revealing mesangial electron-dense deposits (white arrow) and diffuse podocyte foot process effacement (black arrows).
See this image and copyright information in PMC

References

    1. Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. Clin J Am Soc Nephrol. 2017 May;12((5)):825–35. - PMC - PubMed
    1. Gupta R, Sharma A, Bhowmik D, Gupta S, Agarwal S, Gupta R, et al. Collapsing glomerulopathy occurring in HIV-negative patients with systemic lupus erythematosus: report of three cases and brief review of the literature. Lupus. 2011 Jul;20((8)):866–70. - PubMed
    1. Melo NC, Malheiros DM, Barros RT, Woronik V. Collapsing glomerulopathy associated with proliferative lupus nephritis: reversible acute kidney injury. Lupus. 2011 Jan;20((1)):98–101. - PubMed
    1. Tungekar MF, Waller S, Clothier JC. Collapsing glomerulopathy in a girl with systemic lupus erythematosus. Pediatr Nephrol. 2011 May;26((5)):809–13. - PubMed
    1. Salvatore SP, Barisoni LM, Herzenberg AM, Chander PN, Nickeleit V, Seshan SV. Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease. Clin J Am Soc Nephrol. 2012 Jun;7((6)):914–25. - PubMed

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