Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Feb 3;11(1):26-35.
doi: 10.1159/000507424. eCollection 2021 Jan-Apr.

The Use of Supra-Hemodiafiltration in Traumatic Rhabdomyolysis and Acute Kidney Injury: A Case Report

Gabriele Donati  1 , Maria Cappuccilli  1 , Federica Di Filippo  1 , Simone Nicoletti  1 , Marco Ruggeri  1 , Anna Scrivo  1 , Andrea Angeletti  1 , Gaetano La Manna  1
Affiliations
Case Reports

The Use of Supra-Hemodiafiltration in Traumatic Rhabdomyolysis and Acute Kidney Injury: A Case Report

Gabriele Donati et al. Case Rep Nephrol Dial. .

Abstract

Oliguric acute kidney injury due to traumatic rhabdomyolysis can be potentially lethal if the proper medical therapy combined with extracorporeal detoxification is not performed. Different extracorporeal techniques are available to overcome this syndrome. Here, we report the first case of removal of myoglobin and successful recovery from acute kidney injury in an elderly septic patient using supra-hemodiafiltration with endogenous reinfusion technique (HFR-Supra) combined with the medical therapy.

Keywords: Acute kidney injury; Extracorporeal detoxification; HFR-Supra technique; Hemodiafiltration; Myoglobin; Rhabdomyolysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Ecchymosis of the legs at hospital admission.
Fig. 2
Fig. 2
HFR-Supra: schematic diagram. Qb, blood flow; Q plw, plasmatic water flow; kDa, kilodaltons; SC, sieving coefficient.
Fig. 3
Fig. 3
Trends in the reduction of circulating levels of myoglobin (a), CPK (b), LDH (c), CRP (d), and PTC (e) over the 5 days of HFR-Supra treatment. The black line with diamonds represents the analyte levels before the dialysis session and the grey line with squares the ones after the dialysis session. CPK, creatine phosphokinase; CRP, C-reactive protein; LDH, lactate dehydrogenase; PCT, procalcitonin.
Fig. 4
Fig. 4
Sorbent cartridge of HFR-Supra during the detoxification process.
See this image and copyright information in PMC

References

    1. Long B, Koyfman A, Gottlieb M. An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis. Am J Emerg Med. 2019 Mar;37((3)):518–23. - PubMed
    1. Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. N Engl J Med. 2009 Jul;361((1)):62–72. - PubMed
    1. Ronco C. Extracorporeal therapies in acute rhabdomyolysis and myoglobin clearance. Crit Care. 2005 Apr;9((2)):141–2. - PMC - PubMed
    1. Pasquali S, Iannuzzella F, Corradini M, Mattei S, Bovino A, Stefani A, et al. A novel option for reducing free light chains in myeloma kidney: supra-hemodiafiltration with endogenous reinfusion (HFR) J Nephrol. 2015 Apr;28((2)):251–4. - PubMed
    1. Li X, Chen J. Septic shock induced by bacterial prostatitis with Morganella morganii subsp. morganii in a postransplantation patient. Case Rep Transplant. 2015;2015:850532. - PMC - PubMed

Publication types

LinkOut - more resources