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Review
. 2021 Jun;18(3):211-220.
doi: 10.1007/s11904-021-00545-2. Epub 2021 Mar 11.

Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

Daniel C Rogan  1 , Mark Connors  2
Affiliations
Review

Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

Daniel C Rogan et al. Curr HIV/AIDS Rep. 2021 Jun.

Abstract

Purpose of review: A large amount of data now exists on the virus-specific immune response associated with spontaneous or induced immunologic control of lentiviruses. This review focuses on how the current understanding of HIV-specific immunity might be leveraged into induction of immunologic control and what further research is needed to accomplish this goal.

Recent findings: During chronic infection, the function most robustly associated with immunologic control of HIV-1 is CD8+ T cell cytotoxic capacity. This function has proven difficult to restore in HIV-specific CD8+ T cells of chronically infected progressors in vitro and in vivo. However, progress has been made in inducing an effective CD8+ T cell response prior to lentiviral infection in the macaque model and during acute lentiviral infection in non-human primates. Further study will likely accelerate the ability to induce an effective CD8+ T cell response as part of prophylactic or therapeutic strategies.

Keywords: CD8+ T cells; HIV-1 controllers; HIV-1 infection; Immune control; Vaccines; Virus-specific immunity.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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