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. 2021 Jul;156(1):47-58.
doi: 10.1007/s00418-021-01979-w. Epub 2021 Mar 12.

The distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue

Yuchuan Sun  1 , Hong Li  1 , Qiufang Chen  1 , Qing Luo  2 , Guanbin Song  2
Affiliations

The distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue

Yuchuan Sun et al. Histochem Cell Biol. 2021 Jul.

Abstract

The survival of cancer stem cells is usually limited to a specific tumor microenvironment, and this microenvironment plays a vital role in the development of tumors. The mechanical properties of the microenvironment differ in different regions of solid tumors. However, in solid tumors, whether the distribution of cancer stem cells relates to the mechanical microenvironment of different regions is still unclear. In this study, we undertook a biophysical and biochemical assessment of the changes in the mechanical properties of liver tissue during the progression of liver cancer and explored the distribution of liver cancer stem cells in liver cancer tissues. Our analysis confirmed previous observations that the stiffness of liver tissue gradually increased with the progress of fibrosis. In liver cancer tissues, we found obvious mechanical heterogeneity: the core of the tumor was soft, the invasive front tissue was the hardest, and the para-cancer tissue was in an intermediate state. Interestingly, the greatest number of liver cancer stem cells was found in the invasive front part of the tumor. We finally established that stroma stiffness correlated with the number of liver cancer stem cells. These findings indicate that the distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue. This result provides a theoretical basis for the development of targeted therapies against the mechanical microenvironment of liver cancer stem cells.

Keywords: Liver cancer; Liver cancer stem cells; Matrix stiffness; Mechanical heterogeneity.

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References

    1. Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM (2015) Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb) 7(10):1120–1134. https://doi.org/10.1039/c5ib00040h - DOI
    1. Baiocchini A, Montaldo C, Conigliaro A, Grimaldi A, Correani V, Mura F, Ciccosanti F, Rotiroti N, Brenna A, Montalbano M, D’Offizi G, Capobianchi MR, Alessandro R, Piacentini M, Schininà ME, Maras B, Del Nonno F, Tripodi M, Mancone C (2016) Extracellular matrix molecular remodeling in human liver fibrosis evolution. PLoS ONE 11(3):e0151736. https://doi.org/10.1371/journal.pone.0151736 - DOI - PubMed - PMC
    1. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM (2018) A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat Cell Biol 20(10):1203–1214. https://doi.org/10.1038/s41556-018-0183-3 - DOI - PubMed - PMC
    1. Broders-Bondon F, Nguyen Ho-Bouldoires TH, Fernandez-Sanchez ME, Farge E (2018) Mechanotransduction in tumor progression: the dark side of the force. J Cell Biol 217(5):1571–1587. https://doi.org/10.1083/jcb.201701039 - DOI - PubMed - PMC
    1. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S (2018) The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature 563(7730):265–269. https://doi.org/10.1038/s41586-018-0658-1 - DOI - PubMed

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