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. 2021 Apr 1;40(4):344-346.
doi: 10.1097/INF.0000000000002994.

Nevirapine Pharmacokinetics in Neonates Between 25 and 32 Weeks Gestational Age for the Prevention of Mother-to-Child Transmission of HIV

Déborah Hirt  1   2   3 , Jean Kubota Kilengelela  4 , Pierre-Henri Jarreau  4   5 , Jean-Marc Tréluyer  1   2   3 , Valérie Marcou  4
Affiliations

Nevirapine Pharmacokinetics in Neonates Between 25 and 32 Weeks Gestational Age for the Prevention of Mother-to-Child Transmission of HIV

Déborah Hirt et al. Pediatr Infect Dis J. .

Abstract

Eleven newborns from 25 to 32 weeks of gestational age, weighting from 0.66 to 1.60 kg received 2 mg/kg doses of nevirapine syrup. In 15 samples, collected 8.75-89 hours after drug intake, concentrations ranged from 0.65 to 16.68 mg/L. Three nevirapine dose of 2 mg/kg at day 0, 2 and 6 days of life achieved nevirapine concentrations above the proposed nevirapine target for HIV prophylaxis for at least 11 days.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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