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Review
. 2021 Mar 15;402(5):645-651.
doi: 10.1515/hsz-2020-0367. Print 2021 Apr 27.

DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity

Alexandra Z Andreou  1
Affiliations
Review

DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity

Alexandra Z Andreou. Biol Chem. .

Abstract

DEAD-box helicases participate in nearly all steps of an RNA's life. In recent years, increasing evidence has shown that several family members are multitasking enzymes. They are often involved in different processes, which may be typical for RNA helicases, such as RNA export and translation, or atypical, e.g., acting as nucleic acid sensors that activate downstream innate immune signaling. This review focuses on the DEAD-box protein DDX41 and summarizes our current understanding of its roles as an innate immunity sensor in the cytosol and in pre-mRNA splicing in the nucleus and discusses DDX41's involvement in disease.

Keywords: DEAD-box protein; RNA processing; acute myeloid leukemia; innate immunity; myelodysplastic syndrome.

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