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Editorial
. 2021 May;64(5):533-535.
doi: 10.1165/rcmb.2021-0098ED.

Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone

Leonardo Nogueira  1   2 , Ellen C Breen  1
Affiliations
Editorial

Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone

Leonardo Nogueira et al. Am J Respir Cell Mol Biol. 2021 May.
No abstract available

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Figures

Figure 1.
Figure 1.
Mechanism for muscle atrophy owing to chronic cigarette smoke exposure in mice triggered by the expression of RANKL. Three processes may be implicated in RANKL-dependent cigarette smoke–induced atrophy: 1) atrophy-associated gene activation (myostatin and Ubiquitin E3 ligases), 2) activation of proinflammatory cytokines, and 3) myofibrillar contractility controlled by intracellular Ca2+ handling and myofilament function. DHRP = dihydropyridine receptor; OPG = osteoprotegerin; MuRF1 = muscle ring-finger protein 1; RANK = receptor activator of NFκB; RANKL = RANK ligand; RYR = ryanodine receptors; SERCA = SR Ca2+-ATPase; SR = sarcoplasmic reticulum.
See this image and copyright information in PMC

Comment on

References

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