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Review
. 2021 Mar 18;184(6):1469-1485.
doi: 10.1016/j.cell.2021.02.016. Epub 2021 Mar 11.

The basic immunology of asthma

Hamida Hammad  1 , Bart N Lambrecht  2
Affiliations
Free article
Review

The basic immunology of asthma

Hamida Hammad et al. Cell. .
Free article

Erratum in

  • The basic immunology of asthma.
    Hammad H, Lambrecht BN. Hammad H, et al. Cell. 2021 Apr 29;184(9):2521-2522. doi: 10.1016/j.cell.2021.04.019. Cell. 2021. PMID: 33930297 No abstract available.

Abstract

In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as eosinophilia, mucus hypersecretion, bronchial hyperresponsiveness (BHR), IgE production, and susceptibility to exacerbations. However, only half the asthmatics have this "type 2-high" signature, and "type 2-low" asthma is more associated with obesity, presence of neutrophils, and unresponsiveness to corticosteroids, the mainstay asthma therapy. Here, we review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.

Keywords: asthma; biologics; endotypes; immune cells; lung.

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