Comment
doi: 10.1016/j.ccell.2021.02.017.
Epub 2021 Mar 11.
Pancreatic cancer is suppressed by fibroblast-derived collagen I
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- PMID: 33711271
- DOI: 10.1016/j.ccell.2021.02.017
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Comment
Pancreatic cancer is suppressed by fibroblast-derived collagen I
Cancer Cell.
.
Free article
Abstract
Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune suppression and accelerates progression of disease.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer.Cancer Cell. 2021 Apr 12;39(4):548-565.e6. doi: 10.1016/j.ccell.2021.02.007. Epub 2021 Mar 4. Cancer Cell. 2021. PMID: 33667385 Free PMC article.
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