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Comment
. 2021 Apr 12;39(4):451-453.
doi: 10.1016/j.ccell.2021.02.017. Epub 2021 Mar 11.

Pancreatic cancer is suppressed by fibroblast-derived collagen I

Chris D Madsen  1
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Pancreatic cancer is suppressed by fibroblast-derived collagen I

Chris D Madsen. Cancer Cell. .
Free article

Abstract

Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune suppression and accelerates progression of disease.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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