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Review
. 2021 Jul 9;433(14):166929.
doi: 10.1016/j.jmb.2021.166929. Epub 2021 Mar 10.

Structure and Function of Chromatin Remodelers

Alexis A Reyes  1 , Ryan D Marcum  2 , Yuan He  3
Affiliations
Review

Structure and Function of Chromatin Remodelers

Alexis A Reyes et al. J Mol Biol. .

Abstract

Chromatin remodelers act to regulate multiple cellular processes, such as transcription and DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers have been identified in yeast, each with non-redundant roles within the cell. There has been a recent surge in structural models of chromatin remodelers in complex with their nucleosomal substrate. These structural studies provide new insight into the mechanism of action for individual chromatin remodelers. In this review, we summarize available data for the structure and mechanism of action of the four chromatin remodeling complex families.

Keywords: CHD; INO80; ISWI; SWI/SNF; chromatin remodeling.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
Architecture of chromatin remodelers. Structural models of A) SWI/SNF (PDB 6UXW), B) RSC (PSB 6TDA) C) Isw1a (PDB 6JYL), D) Chd1 (PDB 5O9G), E) INO80 (PDB 6FML), and F) SWR1 (PDB 6GEN). Each structural model is colored to denote structural features – nucleosome (grey), ATPase module (green), ARP module (blue), Body module (purple).
See this image and copyright information in PMC

References

    1. Flaus A, Martin DM, Barton GJ, Owen-Hughes T. Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res 2006;34:2887–905. - PMC - PubMed
    1. Sudarsanam P, Winston F. The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Trends Genet 2000;16:345–51. - PubMed
    1. Kubik S, Bruzzone MJ, Challal D, Dreos R, Mattarocci S, Bucher P, et al. Opposing chromatin remodelers control transcription initiation frequency and start site selection. Nat Struct Mol Biol 2019;26:744–54. - PubMed
    1. Rawal Y, Chereji RV, Qiu H, Ananthakrishnan S, Govind CK, Clark DJ, et al. SWI/SNF and RSC cooperate to reposition and evict promoter nucleosomes at highly expressed genes in yeast. Genes Dev 2018;32:695–710. - PMC - PubMed
    1. Clapier CR, Iwasa J, Cairns BR, Peterson CL. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat Rev Mol Cell Biol 2017;18:407–22. - PMC - PubMed

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