A natural killer's hike through epigenetic landscapes

Timo Rückert¹, Chiara Romagnani^{2

3

4}

Affiliations

¹ Innate Immunity, German Rheumatism Research Centre - a Leibniz Institute, Berlin, Germany.
² Innate Immunity, German Rheumatism Research Centre - a Leibniz Institute, Berlin, Germany. romagnani@drfz.de.
³ Medical Department I, Charité University Medicine Berlin, Berlin, Germany.
⁴ Leibniz-Science Campus Chronic Inflammation, Berlin, Germany.

Comment

Timo Rückert et al. Sci Immunol. 2021.

. 2021 Mar 12;6(57):eabf8019.

doi: 10.1126/sciimmunol.abf8019.

Timo Rückert¹, Chiara Romagnani^{2

3

4}

¹ Innate Immunity, German Rheumatism Research Centre - a Leibniz Institute, Berlin, Germany.
² Innate Immunity, German Rheumatism Research Centre - a Leibniz Institute, Berlin, Germany. romagnani@drfz.de.
³ Medical Department I, Charité University Medicine Berlin, Berlin, Germany.
⁴ Leibniz-Science Campus Chronic Inflammation, Berlin, Germany.

Abstract

The transcription factor BCL11B guides NK cells along their differentiation trajectory (see the related Research Article by Holmes et al.).

The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.
Holmes TD, Pandey RV, Helm EY, Schlums H, Han H, Campbell TM, Drashansky TT, Chiang S, Wu CY, Tao C, Shoukier M, Tolosa E, Von Hardenberg S, Sun M, Klemann C, Marsh RA, Lau CM, Lin Y, Sun JC, Månsson R, Cichocki F, Avram D, Bryceson YT. Holmes TD, et al. Sci Immunol. 2021 Mar 12;6(57):eabc9801. doi: 10.1126/sciimmunol.abc9801. Sci Immunol. 2021. PMID: 33712472 Free PMC article.