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Review
. 2021 Mar;22(1):135-143.
doi: 10.1007/s11154-021-09637-1. Epub 2021 Mar 12.

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

Adam Stevens  1 , Reena Perchard  2 , Terence Garner  2 , Peter Clayton  2 , Philip Murray  3
Affiliations
Review

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

Adam Stevens et al. Rev Endocr Metab Disord. 2021 Mar.

Abstract

We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.

Keywords: Growth hormone; Interactome; Pharmacogenomics; Transcriptomics.

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Conflict of interest statement

AS and PM have received speaker honoraria from Merck KGaA, Darmstadt, Germany. PC has received research investigator support and speaker honoraria from Merck KGaA, Darmstadt, Germany.

Figures

Fig. 1
Fig. 1
The small world property of network models. Biological networks are characterised by the aggregation of clusters of genes/proteins (nodes) around central core units that deliver key function. The degree of separation of each gene/protein from the core unit is represented by the colour of the node. Local neighbourhoods are represented by clusters of nodes
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