Review
doi: 10.1007/s11010-021-04121-5.
Epub 2021 Mar 13.
The rise and fall of anandamide: processes that control synthesis, degradation, and storage
Affiliations
- PMID: 33713246
- DOI: 10.1007/s11010-021-04121-5
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Review
The rise and fall of anandamide: processes that control synthesis, degradation, and storage
Mol Cell Biochem.
2021 Jul.
Abstract
Anandamide is an endocannabinoid derived from arachidonic acid-containing membrane lipids and has numerous biological functions. Its effects are primarily mediated by the cannabinoid receptors CB1 and CB2, and the vanilloid TRPV1 receptor. Anandamide is known to be involved in sleeping and eating patterns as well as pleasure enhancement and pain relief. This manuscript provides a review of anandamide synthesis, degradation, and storage and hence the homeostasis of the anandamide signaling system.
Keywords: Anandamide; Endocannabinoid; N-acyltransferase; Phosphatase; Phospholipase.
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References
-
- Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946–1949. https://doi.org/10.1126/science - DOI - PubMed
-
- Maccarrone M (2017) Metabolism of the endocannabinoid anandamide: open questions after 25 years. Front Mol Neurosci 10:166. https://doi.org/10.3389/fnmol.2017.00166 - DOI - PubMed - PMC
-
- Marsicano G, Chaouloff F (2011) Moving bliss: a new anandamide transporter. Nat Neurosci 15:5–6. https://doi.org/10.1038/nn.3011 - DOI - PubMed
-
- Mechoulam R, Parker LA (2013) The endocannabinoid system and the brain. Annu Rev Psychol 64:21–47. https://doi.org/10.1146/annurev-psych-113011-143739 - DOI - PubMed
-
- Ross RA (2003) Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140:790–801. https://doi.org/10.1038/sj.bjp.0705467 - DOI - PubMed - PMC
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