Stimuli-Responsive Multifunctional Phenylboronic Acid Polymers Via Multicomponent Reactions: From Synthesis to Application

Abstract

Stimuli-responsive polymers undergo changes under different environmental conditions. Among them, phenylboronic acid (PBA) containing polymers (PBA-polymers) are unique, because they can selectively react with diols to generate borates that are sensitive to pH, sugars, and H₂ O₂ , and can be effectively used to synthesize smart drug carriers and self-healing hydrogels. Recently, multifunctional PBA-polymers (MF-PBA-polymers) have been developed using multicomponent reactions (MCRs) to introduce PBA groups into polymer structures. These MF-PBA-polymers have features similar to those of traditional PBA-polymers; moreover, they exhibit additional properties, such as fluorescence, antimicrobial activity, and antioxidant capability, when different MCRs are used. In this mini review, the preparation of these MF-PBA-polymers are summarized and the new properties/functions that have been introduced into these polymers using different MCRs are discussed. The uses of these MF-PBA-polymers as fluorescent cell anticoagulants, drug carriers, and gelators of functional self-healing hydrogels have been discussed. Additionally, the challenges encountered during their preparation are discussed and also the future developments in this field are touched upon.

Keywords: hydrogels; multicomponent reactions; phenylboronic acids; stimuli-responsive polymers.