Reducing Radiation-Induced Cognitive Toxicity: Sparing the Hippocampus and Beyond

Kristin J Redmond¹, Michael T Milano², Michelle M Kim³, Daniel M Trifiletti⁴, Scott G Soltys⁵, Jona A Hattangadi-Gluth⁶

Affiliations

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland. Electronic address: kjanson3@jhmi.edu.
² Department of Radiation Oncology, University of Rochester, Rochester, New York.
³ Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
⁴ Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, Florida.
⁵ Department of Radiation Oncology, Stanford University, Stanford, California.
⁶ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.

PMID: 33714520
DOI: 10.1016/j.ijrobp.2021.01.001

Comment

Reducing Radiation-Induced Cognitive Toxicity: Sparing the Hippocampus and Beyond

Kristin J Redmond et al. Int J Radiat Oncol Biol Phys. 2021.

. 2021 Apr 1;109(5):1131-1136.

doi: 10.1016/j.ijrobp.2021.01.001.

Authors

Kristin J Redmond¹, Michael T Milano², Michelle M Kim³, Daniel M Trifiletti⁴, Scott G Soltys⁵, Jona A Hattangadi-Gluth⁶

Affiliations

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland. Electronic address: kjanson3@jhmi.edu.
² Department of Radiation Oncology, University of Rochester, Rochester, New York.
³ Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
⁴ Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, Florida.
⁵ Department of Radiation Oncology, Stanford University, Stanford, California.
⁶ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.

PMID: 33714520
DOI: 10.1016/j.ijrobp.2021.01.001

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Association of Neuronal Injury in the Genu and Body of Corpus Callosum After Cranial Irradiation in Children With Impaired Cognitive Control: A Prospective Study.
Redmond KJ, Hildreth M, Sair HI, Terezakis S, McNutt T, Kleinberg L, Cohen KJ, Wharam M, Horska A, Mahone EM. Redmond KJ, et al. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1234-1242. doi: 10.1016/j.ijrobp.2018.04.037. Epub 2018 Apr 22. Int J Radiat Oncol Biol Phys. 2018. PMID: 29908790 Free PMC article.
Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.
Brown PD, Gondi V, Pugh S, Tome WA, Wefel JS, Armstrong TS, Bovi JA, Robinson C, Konski A, Khuntia D, Grosshans D, Benzinger TLS, Bruner D, Gilbert MR, Roberge D, Kundapur V, Devisetty K, Shah S, Usuki K, Anderson BM, Stea B, Yoon H, Li J, Laack NN, Kruser TJ, Chmura SJ, Shi W, Deshmukh S, Mehta MP, Kachnic LA; for NRG Oncology. Brown PD, et al. J Clin Oncol. 2020 Apr 1;38(10):1019-1029. doi: 10.1200/JCO.19.02767. Epub 2020 Feb 14. J Clin Oncol. 2020. PMID: 32058845 Free PMC article. Clinical Trial.
Microstructural Injury to Corpus Callosum and Intrahemispheric White Matter Tracts Correlate With Attention and Processing Speed Decline After Brain Radiation.
Huynh-Le MP, Tibbs MD, Karunamuni R, Salans M, Tringale KR, Yip A, Connor M, Simon AB, Vitzthum LK, Reyes A, Macari AC, Moiseenko V, McDonald CR, Hattangadi-Gluth JA. Huynh-Le MP, et al. Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):337-347. doi: 10.1016/j.ijrobp.2020.12.046. Epub 2021 Jan 4. Int J Radiat Oncol Biol Phys. 2021. PMID: 33412257 Free PMC article.

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Reducing Radiation-Induced Cognitive Toxicity: Sparing the Hippocampus and Beyond

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Reducing Radiation-Induced Cognitive Toxicity: Sparing the Hippocampus and Beyond

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